Evidence map›Paper›PMID 41314599›Full record

ArticleContemporary clinical trials2026

Effects of daily low oxygen exposure on weight status, body composition, and metabolic health in adults with obesity: protocol for a randomized, double-blind, controlled-feeding study.

Terrence M Riley, Camila Weschenfelder, Eric Ravussin, Jennifer C Rood, Frank Greenway, Sarah Taff, Robert C Hickner, Hongyuan Cao, Angelina R Sutin, Gregory Todd and 2 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07542873 (Effects of Energy Restriction and Intermittent Hypoxia on Iron Absorption in Obesity), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07542873 narecruitingnot on this map

Effects of Energy Restriction and Intermittent Hypoxia on Iron Absorption in Obesity

TypeinterventionalSponsorPennington Biomedical Research CenterRan2025 to 2026Enrolled30ConditionsObesity (Disorder)ArmsNormobaric hypoxia (NH), Normobaric normoxia (NN)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Terrence M RileyPennington Biomedical Research Center, Baton Rouge, LA, USA. Electronic address: terrence.riley@pbrc.edu.
Camila WeschenfelderPennington Biomedical Research Center, Baton Rouge, LA, USA. Electronic address: camila.weschenfelder@pbrc.edu.
Eric RavussinPennington Biomedical Research Center, Baton Rouge, LA, USA. Electronic address: eric.ravussin@pbrc.edu.
Jennifer C RoodPennington Biomedical Research Center, Baton Rouge, LA, USA. Electronic address: jennifer.rood@pbrc.edu.
Frank GreenwayPennington Biomedical Research Center, Baton Rouge, LA, USA. Electronic address: frank.greenway@pbrc.edu.
Sarah TaffPennington Biomedical Research Center, Baton Rouge, LA, USA. Electronic address: sarah.taff@pbrc.edu.
Robert C HicknerFlorida State University, Tallahassee, FL, USA. Electronic address: rhickner@fsu.edu.
Hongyuan CaoFlorida State University, Tallahassee, FL, USA. Electronic address: hcao@fsu.edu.
Angelina R SutinFlorida State University, Tallahassee, FL, USA. Electronic address: angelina.sutin@med.fsu.edu.
Gregory ToddFlorida State University, Tallahassee, FL, USA. Electronic address: gregory.todd@med.fsu.edu.
Stephen R HennigarPennington Biomedical Research Center, Baton Rouge, LA, USA. Electronic address: stephen.hennigar@pbrc.edu.
Claire E BerrymanPennington Biomedical Research Center, Baton Rouge, LA, USA. Electronic address: claire.berryman@pbrc.edu.

Funding

Effects of daily low oxygen exposure on weight status, body composition, and metabolic healthR01DK127162 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI BERRYMAN, CLAIRE E. · 2021 to 2025
$2.1M
NIDDK NIH HHS R01 DK127162
6 · The paper itself

Abstract

backgroundDiet and exercise are the cornerstone of obesity prevention and treatment. However, a substantial number of individuals are non-responsive to existing weight-loss interventions and obesity rates continue to rise. Daily exposure to low-oxygen conditions may aid in current weight-loss strategies by increasing resting metabolic rate and decreasing appetite. Whether in-home, overnight, normobaric hypoxic exposure promotes body weight loss in adults with obesity remains unknown.

methodsFifty adults with obesity (BMI: 30-39.9 kg/m DISCUSSION: Chronic, overnight, low oxygen exposure may provide a novel intervention to supplement current weight-loss strategies, inform new strategies to accelerate weight loss, and aid long-term weight management efforts in adults with obesity. CLINICAL

trial registrationClinicaltrials.govNCT05289310.

Indexed as

ObesityAdultAppetiteBasal MetabolismBody CompositionDiet, ReducingDouble-Blind MethodFemaleHumansMaleMiddle AgedRandomized Controlled Trials as TopicWeight LossYoung AdultEnergy expenditureEnergy restrictionNormobaric hypoxiaWeight loss

Identifiers

PMID41314599
PMCPMC12767485

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.