Evidence map›Paper›PMID 41314150›Full record

ArticleEBioMedicine2025

Quantitative susceptibility mapping at 7T as a biomarker of post- and interictal extravascular iron in patients with focal epilepsy.

Nina Rebecca Held, Tobias Bauer, Rüdiger Stirnberg, Theda von der Recke, Nils Christian Lehnen, Tobias Baumgartner, Juri-Alexander Witt, Attila Rácz, Jan Pukropski, Lennart Walger and 17 more

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Article in EBioMedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Nina Rebecca HeldDepartment of Neuroradiology, University Hospital Bonn, Bonn, Germany; Department of Epileptology, University Hospital Bonn, Bonn, Germany.
Tobias BauerDepartment of Neuroradiology, University Hospital Bonn, Bonn, Germany; Department of Epileptology, University Hospital Bonn, Bonn, Germany; German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Rüdiger StirnbergGerman Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Theda von der ReckeDepartment of Neuroradiology, University Hospital Bonn, Bonn, Germany; Department of Epileptology, University Hospital Bonn, Bonn, Germany.
Nils Christian LehnenDepartment of Neuroradiology, University Hospital Bonn, Bonn, Germany.
Tobias BaumgartnerDepartment of Epileptology, University Hospital Bonn, Bonn, Germany.
Juri-Alexander WittDepartment of Epileptology, University Hospital Bonn, Bonn, Germany.
Attila RáczDepartment of Epileptology, University Hospital Bonn, Bonn, Germany.
Jan PukropskiDepartment of Epileptology, University Hospital Bonn, Bonn, Germany.
Lennart WalgerDepartment of Neuroradiology, University Hospital Bonn, Bonn, Germany; Department of Epileptology, University Hospital Bonn, Bonn, Germany.
Randi von WredeDepartment of Epileptology, University Hospital Bonn, Bonn, Germany.
Mostafa BadrDepartment of Epileptology, University Hospital Bonn, Bonn, Germany.
David WolfDepartment of Epileptology, University Hospital Bonn, Bonn, Germany.
Lennart Nils KerstingDepartment of Neuroradiology, University Hospital Bonn, Bonn, Germany; Department of Epileptology, University Hospital Bonn, Bonn, Germany.
Annalena LangeDepartment of Neuroradiology, University Hospital Bonn, Bonn, Germany; Department of Epileptology, University Hospital Bonn, Bonn, Germany; Institute for Computer Science, University of Bonn, Bonn, Germany.
Justus BistenDepartment of Neuroradiology, University Hospital Bonn, Bonn, Germany; Department of Epileptology, University Hospital Bonn, Bonn, Germany; Institute for Computer Science, University of Bonn, Bonn, Germany.
Markus SchmidtDepartment of Neuroradiology, University Hospital Bonn, Bonn, Germany; Department of Epileptology, University Hospital Bonn, Bonn, Germany.
Eberhard PrachtGerman Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Daniel LöwenGerman Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Jennifer FaberDepartment of Neuroradiology, University Hospital Bonn, Bonn, Germany; German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany; Center for Neurology, Department of Parkinson's Disease, Sleep and Movement Disorders, University Hospital Bonn, Bonn, Germany.
Christoph HelmstaedterDepartment of Epileptology, University Hospital Bonn, Bonn, Germany.
Martin ReuterGerman Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany; A.A. Martinos Centre for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States; Department of Radiology, Harvard Medical School, Boston, MA, United States.
Alon FriedmanDepartment of Brain and Cognitive Sciences, The School of Brain Sciences and Cognition, Zlotowski Centre for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva, Israel; Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel; Department of Medical Neuroscience, Dalhousie University, Halifax, Canada.
Alexander RadbruchDepartment of Neuroradiology, University Hospital Bonn, Bonn, Germany; German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany; Center for Medical Data Usability and Translation, University of Bonn, Bonn, Germany.
Rainer SurgesDepartment of Epileptology, University Hospital Bonn, Bonn, Germany.
Tony StöckerGerman Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department of Physics and Astronomy, University of Bonn, Bonn, Germany.
Theodor RüberDepartment of Neuroradiology, University Hospital Bonn, Bonn, Germany; Department of Epileptology, University Hospital Bonn, Bonn, Germany; German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany; Center for Medical Data Usability and Translation, University of Bonn, Bonn, Germany. Electronic address: theodor.rueber@ukbonn.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIron deposition in the brain has been associated with epilepsy, but its anatomical distribution and its temporal association to seizures remain unclear. Here, we investigate brain iron in individuals with focal epilepsy using interictal and postictal quantitative susceptibility mapping (QSM) at 7 T MRI and explore its functional relevance.

methods80 consecutive participants with focal epilepsy undergoing presurgical evaluation and 50 healthy controls were included. 8/80 participants with focal epilepsy had interictal and postictal scans. High-resolution T1- and susceptibility-weighted images were acquired and processed using custom pipelines for QSM. Seizure onset zones were determined by expert consensus, and neuropsychological assessments included memory and mood. Parcel-wise analyses examined group differences and correlations with cognitive scores, controlling for age and sex.

findingsParticipants with focal epilepsy showed significantly higher interictal susceptibility, which colocalised with the presumed seizure onset zone. Impaired memory performance and more severe depressive symptoms were correlated with higher interictal susceptibility. Postictal susceptibility was significantly higher than interictal susceptibility and associated to the number of preceding seizures.

interpretationQSM reflects both ictal iron extravasation and interictal iron accumulation. If further validated, it may help to non-invasively delineate the epileptogenic zone and become a long-term biomarker for seizure-burden.

fundingN.R.H. and T.Bauer were supported by the BONFOR research commission of the Medical Faculty of the University of Bonn. T.Bauer was funded by the Deutsche Forschungsgemeinschaft. T.Bauer., L.W., A.L. and T.R. are funded by the German Ministry for Research, Technology and Space.

Indexed as

Epilepsies, PartialIronMagnetic Resonance ImagingAdultBiomarkersBrainBrain MappingCase-Control StudiesDisease SusceptibilityFemaleHumansMaleMiddle AgedYoung AdultBiomarkersIronBlood–brain-barrier dysfunctionNeuroinflammationPostictal imagingUltra-high-field MRI

Identifiers

PMID41314150
PMCPMC12703981

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.