Evidence map›Paper›PMID 41313802›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

NIR Ratiometric Fluorescent Antibody-Drug Conjugate for Metastatic Ovarian Cancer Theranostics and Treatment Response Monitoring.

Cheng Li, Zezhong Yu, Tao Pu, Yanling Wu, Gang Wang, Youhua Xie, Tianlei Ying, Zhenlin Yang, Yibing Shi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cheng LiShanghai Institute of Infectious Disease and Biosecurity, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Obstetrics & Gynecology Hospital of Fudan University, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Zezhong YuDepartment of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Tao PuShanghai Institute of Infectious Disease and Biosecurity, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Obstetrics & Gynecology Hospital of Fudan University, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Yanling WuShanghai Institute of Infectious Disease and Biosecurity, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Obstetrics & Gynecology Hospital of Fudan University, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Gang WangShanghai Institute of Infectious Disease and Biosecurity, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Obstetrics & Gynecology Hospital of Fudan University, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Youhua XieShanghai Institute of Infectious Disease and Biosecurity, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Obstetrics & Gynecology Hospital of Fudan University, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Tianlei YingShanghai Institute of Infectious Disease and Biosecurity, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Obstetrics & Gynecology Hospital of Fudan University, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Zhenlin YangDepartment of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Yibing ShiShanghai Institute of Infectious Disease and Biosecurity, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Obstetrics & Gynecology Hospital of Fudan University, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.ORCID https://orcid.org/0009-0004-5348-4747

Funding

China National Postdoctoral Program for Innovative Talents BX20240076Fund of Fudan University and Cao'ejiang Basic Research 24FCB09National Key Research and Development Program of China 2024YFA1803100National Natural Science Foundation of China 32270984National Natural Science Foundation of China 82322001National Natural Science Foundation of China 82394450National Natural Science Foundation of China 82495204National Natural Science Foundation of China 92459301Science and Technology Commission of Shanghai Municipality 23QA1401200Science and Technology Commission of Shanghai Municipality 23XD1400800Shanghai Municipal Health Commission Project 20244Y0058Shanghai Municipal Science and Technology Major Project ZD2021CY001Starlight Program Sailing Special Project 24YF2706100
6 · The paper itself

Abstract

In vivo optical imaging advances antibody-drug conjugate (ADC) optimization by enabling real-time monitoring of biological stimulus-responsive drug behavior. Ratiometric probes, incorporating orthogonal wavelength-encoded multicolor detection and stimuli-cleavable linkages, are preferred over single-color strategies. Here, the synthesis of n501-CYMMAF (cyanine-decorated Monomethylauristatin F) is described as a novel ratiometric theranostic agent for dual efficacy in ovarian metastasis treatment and in situ treatment response monitoring. With low-dose administration (2.5 mg kg

Indexed as

ImmunoconjugatesOvarian NeoplasmsTheranostic NanomedicineAnimalsCell Line, TumorFemaleHumansMiceOptical ImagingImmunoconjugatesfluorescent antibody‐drug conjugatein situ treatment response monitoringnear infrared bioimagingovarian metastases treatmentratiometric probe

Identifiers

PMID41313802
PMCPMC12866695

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.