Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
25 authors.
Manuel RoggInstitute of Surgical Pathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.ORCID 0000-0002-6658-9159
Lisa WeißerInstitute of Surgical Pathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Jasmin I MaierInstitute of Surgical Pathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.ORCID 0000-0003-4158-2935
August SigleDepartment of Urology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.ORCID 0000-0001-6857-8149
Martin HelmstädterDepartment of Medicine IV, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.ORCID 0000-0001-6027-0094
Marlene StiglerInstitute of Surgical Pathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Alena SammarcoInstitute of Surgical Pathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Katja GräweInstitute of Surgical Pathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Grigor AndreevInstitute of Surgical Pathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.ORCID 0009-0008-3808-8331
Charlotte KarkInstitute of Surgical Pathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Suresh K RamakrishnanSektion Nephrogenetik, Institute of Human Genetics, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Cem ÖzelDepartment II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0009-0006-7091-7027
Linus ButtDepartment II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-2568-2998
Frederic ArnoldDepartment of Medicine IV, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.ORCID 0000-0001-6799-9152
Wibke Bechtel-WalzDepartment of Medicine IV, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.ORCID 0000-0001-6032-3627
Oliver SchillingInstitute of Surgical Pathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.ORCID 0000-0001-7678-7653
Yakup TanriverDepartment of Medicine IV, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.ORCID 0000-0002-4806-2548
Paul BrinkkötterDepartment II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0002-4287-2080
Markus GrabbertDepartment of Urology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Matias SimonsSektion Nephrogenetik, Institute of Human Genetics, University Hospital Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0003-3959-6350
Martin WernerInstitute of Surgical Pathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Oliver KretzIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0003-1152-5956
Thomas BenzingDepartment II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0003-0512-1066
Tobias B HuberIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0001-7175-5062
Christoph SchellInstitute of Surgical Pathology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.ORCID 0000-0001-5344-624X
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
Proteinuric kidney disease substantially affects renal tubules through incompletely understood mechanisms. We identify elongation of primary cilia in distal renal tubules in the context of glomerular nephropathy. In renal biopsies and mouse models, tubular injury correlates with ciliary elongation, tubule dilation, and disruption of the cortical actin cytoskeleton. In vitro studies implicate biophysical cues of the glomerular filtrate and subsequent dysregulation of the actin cytoskeleton as contributing factors, confirmed by conditional deletion of N-WASP and Arp2/3 in vivo and in vitro. Electron and fluorescence microscopy revealed enlarged ciliary pockets, basal body mislocalization, and intracellular cilia formation in
Indexed as
Actin-Related Protein 2-3 ComplexCiliaEpithelial CellsKidney DiseasesKidney Tubules, DistalActin CytoskeletonAnimalsDisease Models, AnimalHumansMiceMice, KnockoutActin-Related Protein 2-3 Complex
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Arp2/3-dependent regulation of ciliogenesis governs adaptive distal tubular epithelial cell states in kidney disease. · full record | OpenQuestion