Evidence map›Paper›PMID 41313768›Full record

ArticleScience advances2025

Cortical dopaminergic signaling mediates planning of directional movements.

John Chen, Alfredo Fontanini

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

John ChenGraduate Program in Neuroscience, Stony Brook University, Stony Brook, NY 11794, USA.ORCID 0000-0002-4335-041X
Alfredo FontaniniGraduate Program in Neuroscience, Stony Brook University, Stony Brook, NY 11794, USA.ORCID 0000-0003-4561-9563

Funding

Gustatory cortex and reward-based, taste-action associationsR01DC018227 · NIDCD · STATE UNIVERSITY NEW YORK STONY BROOK · PI FONTANINI, ALFREDO · 2019 to 2023
$2.2M
The role of cortical D1R-expressing neurons in taste-based sensorimotor transformationsF31DC020648 · NIDCD · STATE UNIVERSITY NEW YORK STONY BROOK · PI CHEN, JOHN · 2022 to 2023
$79k
NIDCD NIH HHS F31 DC020648NIDCD NIH HHS R01 DC018227
6 · The paper itself

Abstract

The anterior-lateral motor cortex (ALM) has been extensively studied as a model for understanding the cortical mechanisms involved in planning directional movements. ALM neurons show preparatory activity that predict whether the mouse will produce a left- or right-directed lick. While the neural mechanisms underlying ALM dynamics and their links to behavior are beginning to be elucidated, the sources of this directional activity remain unclear. Here, we examined the role of ALM dopaminergic circuits in mice performing a directional licking task. We report that dopamine (DA) signals and the activity of neurons expressing D1 receptors (D1R

Indexed as

DopamineDopaminergic NeuronsMotor CortexSignal TransductionAnimalsMaleMiceMovementOptogeneticsReceptors, Dopamine D1DopamineReceptors, Dopamine D1

Identifiers

PMID41313768
PMCPMC12662208

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.