Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
22 authors.
Anika SpreenInstitute for Biology, Experimental Biophysics, Humboldt-Universität zu Berlin, 10115 Berlin, Germany.ORCID 0009-0002-5649-4364
Nidish Ponath SadanandanMax Planck Institute for Neurobiology of Behavior - caesar, Ludwig-Erhard-Allee 2, 53175 Bonn, Germany.ORCID 0000-0003-1534-831X
Martin Winfried SchneiderDepartment Genes-Circuits-Behavior, Max Planck Institute for Biological Intelligence, Am Klopferspitz 18, 82152 Martinsried, Germany.ORCID 0000-0001-9760-6292
Enrico KuehnDepartment Genes-Circuits-Behavior, Max Planck Institute for Biological Intelligence, Am Klopferspitz 18, 82152 Martinsried, Germany.ORCID 0000-0003-3428-5860
Andries Napo LeemisaInstitute for Experimental Cardiovascular Medicine, University Heart Center, Medical Center-University of Freiburg, and Faculty of Medicine, University of Freiburg, Elsässer Str. 4C, 79110 Freiburg, Germany.ORCID 0009-0009-8156-2155
Roberta De ZioInstitute for Experimental Cardiovascular Medicine, University Heart Center, Medical Center-University of Freiburg, and Faculty of Medicine, University of Freiburg, Elsässer Str. 4C, 79110 Freiburg, Germany.ORCID 0000-0002-1777-2088
Niklas MeyerNeuroscience Research Center, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.ORCID 0009-0004-6794-1267
Wayne BusseInstitute for Biology, Experimental Biophysics, Humboldt-Universität zu Berlin, 10115 Berlin, Germany.ORCID 0009-0006-4364-7914
Bela ErlinghagenMedical Faculty, Institute for Experimental Epileptology and Cognition Research, University of Bonn, Venusberg Campus 1, 53127 Bonn, Germany.ORCID 0009-0002-3198-3137
Lea AdenauerMedical Faculty, Institute for Experimental Epileptology and Cognition Research, University of Bonn, Venusberg Campus 1, 53127 Bonn, Germany.
Thoralf OpitzMedical Faculty, Institute for Experimental Epileptology and Cognition Research, University of Bonn, Venusberg Campus 1, 53127 Bonn, Germany.ORCID 0009-0001-2419-5004
Wolfgang BönigkMax Planck Institute for Neurobiology of Behavior - caesar, Ludwig-Erhard-Allee 2, 53175 Bonn, Germany.
Enrico SchiewerInstitute for Biology, Experimental Biophysics, Humboldt-Universität zu Berlin, 10115 Berlin, Germany.ORCID 0000-0001-7913-5597
Jonas HeerInstitute for Experimental Cardiovascular Medicine, University Heart Center, Medical Center-University of Freiburg, and Faculty of Medicine, University of Freiburg, Elsässer Str. 4C, 79110 Freiburg, Germany.ORCID 0009-0003-1844-5331
Dietmar SchmitzNeuroscience Research Center, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.ORCID 0000-0003-2741-5241
Johannes VierockNeuroscience Research Center, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.ORCID 0000-0001-7368-5539
Heinz BeckMedical Faculty, Institute for Experimental Epileptology and Cognition Research, University of Bonn, Venusberg Campus 1, 53127 Bonn, Germany.ORCID 0000-0002-8961-998X
Peter HegemannInstitute for Biology, Experimental Biophysics, Humboldt-Universität zu Berlin, 10115 Berlin, Germany.ORCID 0000-0003-3589-6452
Herwig BaierDepartment Genes-Circuits-Behavior, Max Planck Institute for Biological Intelligence, Am Klopferspitz 18, 82152 Martinsried, Germany.ORCID 0000-0002-7268-0469
Franziska Schneider-WarmeInstitute for Experimental Cardiovascular Medicine, University Heart Center, Medical Center-University of Freiburg, and Faculty of Medicine, University of Freiburg, Elsässer Str. 4C, 79110 Freiburg, Germany.ORCID 0000-0002-5873-9436
Yinth Andrea Bernal SierraInstitute for Biology, Experimental Biophysics, Humboldt-Universität zu Berlin, 10115 Berlin, Germany.ORCID 0000-0003-3067-7496
Reinhard SeifertMax Planck Institute for Neurobiology of Behavior - caesar, Ludwig-Erhard-Allee 2, 53175 Bonn, Germany.ORCID 0009-0003-5872-4845
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
Since the advent of optogenetics, great progress has been made in developing tools to modulate and detect cellular activity using light. We present a two-component optogenetic silencing tool, RoCK (rhodopsin cyclase/K
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Optogenetic silencing by combining a rhodopsin cyclase with an engineered cGMP-gated potassium channel. · full record | OpenQuestion