Evidence map›Paper›PMID 41313759›Full record

ArticleScience advances2025

Complementary roles of dorsal and ventral hippocampus in the flexible adaptation of goal-directed behavior.

Maryam Hasantash, Yifei Li, Arturo Torres-Herraez, Christoph Kellendonk, Christoph Anacker

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maryam HasantashDepartment of Psychiatry, Division of Systems Neuroscience, Columbia University, New York, NY, USA.ORCID 0009-0006-4527-4197
Yifei LiResearch Foundation for Mental Hygiene, New York State Psychiatric Institute, New York, NY, USA.ORCID 0009-0000-1136-6305
Arturo Torres-HerraezResearch Foundation for Mental Hygiene, New York State Psychiatric Institute, New York, NY, USA.ORCID 0000-0001-6333-5623
Christoph KellendonkDepartment of Psychiatry, Division of Systems Neuroscience, Columbia University, New York, NY, USA.ORCID 0000-0003-3302-2188
Christoph AnackerDepartment of Psychiatry, Division of Systems Neuroscience, Columbia University, New York, NY, USA.ORCID 0000-0002-9880-6760

Funding

Translational Neuroscience Training Grant.T32MH015174 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DENNY, CHRISTINE ANN · 1985 to 2020
$4.0M
INVESTIGATING THE ROLE OF HIPPOCAMPUS - ORBITOFRONTAL CIRCUITS FOR COGNITIVE FLEXIBILITYR01MH126105 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI Christoph Anacker · 2022 to 2026
$3.6M
Co-Regulation of Striatal Dopamine and Acetylcholine During Flexible LearningR01MH124858 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI KELLENDONK, CHRISTOPH · 2021 to 2025
$2.7M
Striatal Regulation of Cortical Acetylcholine ReleaseR21MH126380 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI KELLENDONK, CHRISTOPH · 2022 to 2023
$430k
NIMH NIH HHS R01 MH124858NIMH NIH HHS R01 MH126105NIMH NIH HHS R21 MH126380NIMH NIH HHS T32 MH015174
6 · The paper itself

Abstract

The ability to adapt previously learned behaviors is crucial for survival in dynamically changing environments. The hippocampus has been implicated in associative learning, but how hippocampus activity along its septotemporal axis contributes to flexible adaptation is unknown. Using in vivo Ca

Indexed as

Adaptation, PhysiologicalBehavior, AnimalCA1 Region, HippocampalGoalsHippocampusAnimalsMaleMiceMice, Inbred C57BLNeurons

Identifiers

PMID41313759
PMCPMC12662218

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.