SynthesisAddiction biology2025
Functional Connectivity Disruptions in Grey Matter Volume-Altered Brain Regions Among Male Smokers: A Neuroimaging Study.
Synthesis in Addiction biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Functional Connectivity Disruptions in Grey Matter Volume-Altered Brain Regions Among Male Smokers: A Neuroimaging Study.Addiction biology · 2025Pooled it
- Cerebellar hypermetabolism disrupts fronto-cerebellar resting-state functional connectivity and associated executive compensation.Translational psychiatry · 2026Article
- Investigation of cerebral cortical morphological similarity and network topological abnormalities in hepatic encephalopathy utilizing a morphometric inverse divergence network framework.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
This study aimed to investigate whether structural brain alterations in smokers are accompanied by synchronized changes in functional connectivity, with a focus on understanding the neural mechanisms underlying smoking addiction. We conducted a meta-analysis of voxel-based morphometry (VBM) studies using the Seed Mapping software package to identify consistent grey matter changes in smokers' brains, which were subsequently defined as regions of interest (ROIs). Resting-state functional connectivity between these ROIs and whole-brain voxels was analysed in 53 male smokers and 38 non-smokers. Additional correlation analyses were performed to assess relationships with clinical features. Smokers exhibited reduced functional connectivity between the right lingual gyrus (which showed increased grey matter volume) and the left calcarine sulcus. The right superior frontal gyrus (with decreased grey matter volume) suggested diminished functional connectivity with multiple regions, including the bilateral precentral and postcentral gyrus, left rolandic operculum, left inferior frontal gyrus (opercular part), left midcingulate cortex, bilateral supplementary motor area, left paracentral lobule, right inferior frontal gyrus (triangular part) and right middle frontal gyrus (GRF corrected, voxel-level p < 0.001, cluster-level p < 0.05). Notably, reduced connectivity of some brain regions to the right superior frontal gyrus was negatively correlated with the Fagerström Test for Nicotine Dependence (FTND). Our findings demonstrate that structural brain alterations in smokers are associated with specific disruptions in functional connectivity, particularly within visual attention, executive control and sensorimotor networks. These results provide additional evidence of the neuropathophysiological mechanisms underlying smoking addiction.
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Registered trials
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