ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025
Altered Lipid Metabolism in the Vaginal Wall of Women With Pelvic Organ Prolapse: A Targeted Lipidomics Study.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Raman spectroscopy for nondestructive detection of vaginal tissue alterations in the fibulin-5 murine model of pelvic organ prolapse.Biophotonics discovery · 2026Article
- Association between glucose and lipid metabolism-related indicators and the occurrence and severity of pelvic organ prolapse in postmenopausal women.Frontiers in medicine · 2026Article
- Altered Lipid Metabolism in the Vaginal Wall of Women With Pelvic Organ Prolapse: A Targeted Lipidomics Study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
Pelvic organ prolapse (POP) severely impacts quality of life, but its association with lipid metabolism remains unclear. This study explored lipidomic alterations in vaginal anterior wall tissues of POP patients. We performed UHPLC-MS/MS-based targeted lipidomics on vaginal anterior wall tissues from 8 POP patients and 8 matched controls. Multivariate analyses (PCA, PLS-DA, OPLS-DA) identified significantly altered lipids, and KEGG pathway analysis determined related metabolic pathways. Among 1010 identified lipids, POP tissues exhibited significant lipid remodeling: phosphatidic acid (PA) increased from 0.048% to 0.226%, triglycerides (TG) decreased from 94.901% to 83.927%. Forty- four lipids were significantly altered (VIP > 1, p < 0.05), with KEGG analysis highlighting enrichment in glycerophospholipid metabolism. Reprogramming of lipid chain length and saturation further confirmed metabolic dysregulation. POP may be associated with disrupted lipid metabolism, characterized by elevated PA/PE/PC and reduced TG, potentially impairing membrane stability, mitochondrial function, and energy homeostasis. These findings reveal novel molecular mechanisms in POP and suggest lipid metabolism as a therapeutic target.
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Registered trials
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