ReviewDiscover oncology2025
A comprehensive review redefining viruses as therapeutic agents in cancer treatment.
Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Integrating oncolytic adenoviruses into combination cancer therapy: Mechanisms, advances and clinical outlook.Clinical and translational medicine · 2026Review
- The interplay between oncolytic viruses, Toll-like receptor signaling, and chemotherapy in overcoming tumor immune tolerance.Frontiers in cellular and infection microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oncolytic viruses (OVs) possess the distinctive capability to selectively eliminate malignant cells while exerting reduced impact on healthy tissues compared to traditional therapies. This unique attribute renders them valuable candidates for the development of anti-cancer therapeutics. The recognition of OVs dates to historical observations of tumor regression associated with systemic viral infections. Current advancements in technology enable us to harness this knowledge for therapeutic purposes. However, owing to their inherent pathogenic nature, OVs require genetic modifications to attenuate their virulence, heighten their specificity, and enhance their immunogenic properties. Within the scope of this review, we explore a range of strategies aimed at augmenting the therapeutic potential of OVs. Furthermore, we underscore the synergistic advantages achieved by combining OVs with other cancer treatment modalities. A detailed elucidation of the oncolytic mechanism executed by OVs is provided, and brief mentions are made regarding the positive outcomes observed in clinical trials involving selected OVs. Recent progress in oncolytic viral immunotherapy, exemplified by the utilization of non-infectious Plant virus-based Nanoparticles (PVNPs) in mammals and the application of the Zika virus in glioblastoma treatment, heralds a promising era for innovative therapeutic approaches in the battle against cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.