ArticleMolecular biology reports2025
The role of miR-34a gene expression in Zearalenone-mediated toxicity in vitro: the protective effect of Lactobacillus acidophilus.
Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundZearalenone (ZEN), an important mycotoxin produced by Fusarium species, poses significant health threat due to estrogenic and cytotoxic effects. This study aimed to investigate protective effects of Lactobacillus acidophilus (L. acidophilus) against on ZEN-induced cytotoxicity and its influence on miRNA-34a expression in HepG2 cell line.
methodsHepG2 cells were seeded in 96-well plates and incubated at 37 °C for 24 h; then survival rate of HepG2 cells treated with different concentrations of 100-200µM zearalenone and probiotics was calculated using MTT method and IC50 value was calculated using Prism version 9 software. Lactate dehydrogenase activity, a marker of cellular damage, was measured. Additionally, the expression of miRNA-34a, a microRNA potentially involved in ZEN-mediated cytotoxicity, was quantified using real-time PCR with specific primers.
resultsThe expression of miRNA-34a gene in HepG2 cells exposed to ZEN treated with L. acidophilus.
conclusionThe results of the present study showed probiotics moderate the toxic effects of this mycotoxin.
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