Evidence map›Paper›PMID 41313489›Full record

ArticleArchives of virology2025

Transcriptomic analysis reveals Rnd1 to be a key player in antiviral immunity against Akabane virus via the TNF-α pathway.

Dongjie Chen, Jingjing Wang, Chao Sun, Fang Wei, Shengkui Xu, Ruyang Yu, Shaoqiang Wu

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dongjie ChenInstitute of Animal Inspection and Quarantine, Chinese Academy of Quality and Inspection & Testing, No. 11, Ronghuanan Road, Beijing, 100176, China.
Jingjing WangInstitute of Animal Inspection and Quarantine, Chinese Academy of Quality and Inspection & Testing, No. 11, Ronghuanan Road, Beijing, 100176, China.
Chao SunState Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
Fang WeiInstitute of Animal Inspection and Quarantine, Chinese Academy of Quality and Inspection & Testing, No. 11, Ronghuanan Road, Beijing, 100176, China.
Shengkui XuCollege of Animal Science and Technology, Beijing University of Agriculture, Beijing, 102206, China.
Ruyang YuInstitute of Animal Inspection and Quarantine, Chinese Academy of Quality and Inspection & Testing, No. 11, Ronghuanan Road, Beijing, 100176, China.
Shaoqiang WuInstitute of Animal Inspection and Quarantine, Chinese Academy of Quality and Inspection & Testing, No. 11, Ronghuanan Road, Beijing, 100176, China. sqwu@sina.com.ORCID http://orcid.org/0000-0002-3255-8020

Funding

the National Key R&D Program of China 2022YFD1802000the Natural Science Foundation of Beijing 6254044
6 · The paper itself

Abstract

Akabane virus (AKAV), the etiological agent of Akabane disease, is known to induce congenital malformations and neuropathologies in the fetuses of pregnant cattle and sheep. To analyze the changes in gene expression patterns that occur in AKAV-infected cells, two types of primary bovine cells - primary bovine testicular Sertoli cells (BTSCs) and primary bovine joint synovial cells (BJSCs) - were selected. These cells were confirmed to be infected by AKAV strain TJ2016. Subsequently, RNA-sequencing technology was employed to analyze the transcriptomic profiles of AKAV-infected BTSCs and BJSCs, as well as Madin-Darby ovine kidney (MDOK) cells. The AKAV-infected cells exhibited activation of antiviral signaling pathways. Notably, there was upregulation of the expression levels of interferon-stimulated genes, as well as genes related to inflammation and cytokines. IL-1β, TNF-α, CXCL8, CCL2, and Rnd1 were found to be significantly upregulated in AKAV-infected cells. Moreover, Rnd1 was found to inhibit the replication of AKAV. Because TNF-α plays an important role in the induction of Rnd1, this provides additional evidence for the regulation and function of Rnd1.

Indexed as

Bunyaviridae InfectionsOrthobunyavirusrho GTP-Binding ProteinsTumor Necrosis Factor-alphaAnimalsCattleCell LineCells, CulturedGene Expression ProfilingMaleSertoli CellsSheepSignal TransductionTranscriptomeVirus Replicationrho GTP-Binding ProteinsTumor Necrosis Factor-alphaAkabane virusRnd1TNF-α signaling pathwayTranscriptomic analysis

Identifiers

PMID41313489

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.