Evidence map›Paper›PMID 41313486›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

PET/MRI as a complement to PET/CT in chronic osteomyelitis with soft-tissue involvement: implications for surgical outcomes.

Heng Wu, Xiao Ma, Haijian Li, Qiao Wu, Zhenyu Jiang, Tianyu Xi, Yi Shou, Pei Han

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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [Clinical evaluation and repair strategies for complex inguinal wounds].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Heng Wu *Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, 200233, P. R. China.
Xiao Ma *Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, 200233, P. R. China.
Haijian LiShanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, 200233, P. R. China.
Qiao WuShanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, 200233, P. R. China.
Zhenyu JiangShanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, 200233, P. R. China.
Tianyu XiShanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, 200233, P. R. China.
Yi ShouDepartment of Medical Imaging, Shanghai Meizhong Jiahe Medical Imaging Center, Shanghai, 201107, P. R. China. evan_sh@sina.com.
Pei HanShanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, 200233, P. R. China. hanpei_cn@163.com.ORCID 0000-0002-6078-3815

Funding

National Key Research and Development Program of China No. 2023YFC2410804Science and Technology Commission of Shanghai Municipality No.23Y11908200
6 · The paper itself

Abstract

purposeChronic osteomyelitis with soft-tissue involvement carries high risks of recurrence and reoperation. Accurate preoperative delineation of bone and soft-tissue infection is critical but challenging with conventional imaging. [¹⁸F]fluorodeoxyglucose positron emission tomography/computed tomography ([¹⁸F]FDG PET/CT) is sensitive for osseous lesions but limited for soft tissue, while magnetic resonance imaging (MRI) provides soft-tissue detail but lacks specificity. This study evaluated whether hybrid positron emission tomography/magnetic resonance imaging (PET/MRI) could overcome these limitations and improve surgical management.

methodsWe retrospectively reviewed 52 patients with chronic osteomyelitis and soft-tissue infection (2018-2024). Patients were stratified into a combined group (PET/CT + PET/MRI, n = 10) and a standard group (PET/CT + MRI, n = 42). Imaging accuracy was compared with intraoperative findings. Twelve-month outcomes included recurrence-free survival (RFS), functional recovery [Lower Extremity Functional Scale (LEFS), Musculoskeletal Tumor Society (MSTS) score], and neurovascular complications.

resultsPET/CT identified cortical destruction and intraosseous infection but underestimated soft-tissue involvement. PET/MRI delineated abscesses, sinus tracts, and muscle infiltration with close concordance to surgical findings and less overestimation than MRI. The combined group showed lower recurrence (10.0% vs. 35.7%), longer RFS, and superior function (LEFS 55.7 ± 7.1 vs. 48.3 ± 7.4; MSTS 19.6 ± 2.1 vs. 16.4 ± 2.4; all p < 0.05). Neurovascular complication rates were also reduced (10.0% vs. 21.4%).

conclusionPET/MRI integrated with PET/CT improved infection mapping, guided precise debridement, and was associated with reduced recurrence, better recovery, and enhanced neurovascular safety. These findings support PET/MRI as a valuable adjunct in complex chronic osteomyelitis, warranting validation in larger studies.

Indexed as

Magnetic Resonance ImagingOsteomyelitisPositron Emission Tomography Computed TomographySoft Tissue InfectionsAdolescentAdultAgedChronic DiseaseFemaleHumansMaleMiddle AgedMultimodal ImagingRetrospective StudiesTreatment OutcomeYoung AdultBone–soft tissue composite infectionChronic osteomyelitisNeurovascular preservationPET/MRIRecurrence-free survival

Identifiers

PMID41313486

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.