ArticleArchives of microbiology2025
Investigating in vitro antifungal mechanisms of geraniol against Candida albicans.
Article in Archives of microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Plant essential oils against woody plant fungal pathogens: chemical composition, antifungal mechanisms, and translational challenges.Plant signaling & behavior · 2026Review
- Article
- Phytochemical Characterisation and Skin-Relevant In Vitro Biological Activity of Leaf Extracts from SelectedMolecules (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the antifungal mechanisms of geraniol against Candida albicans. Geraniol significantly inhibited growth and biofilm formation, with a minimum inhibitory concentration (MIC) of 0.5 µL/mL. At concentrations of 0.3, 0.45, and 0.6 µL/mL, geraniol substantially reduced biofilm biomass (P < 0.05). Microscopic analyses revealed apoptosis induction, membrane shrinkage, and structural damage. Mechanistically, geraniol disrupted cell membrane permeability, inhibited ergosterol synthesis, and downregulated the expression of key virulence genes (SAP5, SAP6, SAP7). These multifaceted mechanisms highlight geraniol as a promising antifungal candidate with potential clinical relevance in combating antifungal resistance. Future studies should include vivo validation to explore its therapeutic application.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.