ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2026
Association of delayed apophyseal ring maturation with juvenile lumbar disc herniation: a retrospective case-control study with CT-based staging.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate the association between delayed apophyseal ring (AR) maturation and juvenile lumbar disc herniation (JDH), and to characterize the associated patterns of AR separation and spatial development.
methodThis retrospective case-control study evaluated CT scans from 180 JDH patients and 178 matched controls aged 12 to 20. We graded AR maturation (S0-S4) and assessed its association with JDH via logistic regression.
resultsJDH patients showed significant AR maturation delays of 1-2 years compared to controls. After adjusting for age and sex, JDH remained associated with lower odds of achieving AR maturity (OR = 0.277, P < 0.001). In patients with JDH, AR separation was present in 30.8% of herniated segments, with incidence increasing significantly after age 17. Furthermore, JDH patients demonstrated altered terminal spatial patterns of AR maturation (P < 0.001).
conclusionsA strong association exists between delayed AR maturation and JDH. JDH patients also demonstrated altered terminal spatial patterns of AR maturation and a high incidence of AR separation after age 17. These findings suggest that JDH pathogenesis may be associated with developmental factors, highlighting the need for future research to explore these associations.
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