Evidence map›Paper›PMID 41313432›Full record

Trial reportObesity surgery2026

The Effect of Increased Sodium Intake with a Carbohydrate-Rich Meal on Glucose Homeostasis in People without Diabetes after Roux-en-Y Gastric Bypass: a Proof-of-Concept, Randomized, Open-Label, Crossover Study.

Stanislava Katsarova-Harrison, Gráinne Whelehan, Joseph Henson, Louisa Y Herring, David Bowrey, Alice E Thackray, David J Stensel, Iskander Idris, Oluwaseun Anyiam, Anjali Zalin and 5 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Obesity surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Stanislava Katsarova-HarrisonDiabetes Research Centre, University of Leicester College of Life Sciences, Leicester, UK. s.s.katsarova@lboro.ac.uk.
Gráinne WhelehanDiabetes Research Centre, University of Leicester College of Life Sciences, Leicester, UK.
Joseph HensonLeicester Diabetes Centre, Leicester General Hospital, Leicester, UK.
Louisa Y HerringLeicester Diabetes Centre, Leicester General Hospital, Leicester, UK.
David BowreyDepartment of Surgery, University Hospitals of Leicester NHS Trust, Leicester General Hospital, Leicester, UK.
Alice E ThackrayNational Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
David J StenselNational Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
Iskander IdrisEast-Midlands Bariatric & Metabolic Institute, University Hospital of Derby and Burton Foundation Trust, Derby, UK.
Oluwaseun AnyiamEast-Midlands Bariatric & Metabolic Institute, University Hospital of Derby and Burton Foundation Trust, Derby, UK.
Anjali ZalinBedfordshire Hospitals NHS Foundation Trust, Luton, UK.
Alan AskariBedfordshire Hospitals NHS Foundation Trust, Luton, UK.
David R WebbDiabetes Research Centre, University of Leicester College of Life Sciences, Leicester, UK.
Tom YatesDiabetes Research Centre, University of Leicester College of Life Sciences, Leicester, UK.
Melanie J DaviesDiabetes Research Centre, University of Leicester College of Life Sciences, Leicester, UK.
Dimitris PapamargaritisDiabetes Research Centre, University of Leicester College of Life Sciences, Leicester, UK. dp421@leicester.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRoux-en-Y gastric bypass (RYGB) induces substantial weight loss and changes in glucose homeostasis, partly through alterations in gastrointestinal anatomy and nutrient absorption. Sodium-glucose co-transporters-1 (SGLT-1) facilitate intestinal glucose absorption, a process that may be compromised post-RYGB. Animal studies suggest that sodium supplementation to a meal may enhance SGLT-1 activity post-RYGB. In this study, we investigated whether adding sodium chloride (NaCl) to a carbohydrate-rich meal affects glucose homeostasis in people after RYGB.

methodsIn this open-label, randomized, crossover study, eleven adults without diabetes post-RYGB (mean age 57.3 ± 11.3 years, BMI 35.1 ± 7.5 kg/m2, 64% female) underwent two mixed meal tolerance tests (MMTT), on separate days, either with or without 2 g of additional NaCl (785 mg sodium). The primary outcome was the difference in nadir postprandial plasma glucose between conditions. Secondary outcomes included differences in area under the curve (AUC

resultsThe addition of 2 g NaCl did not alter nadir plasma glucose (3.7 mmol/L with NaCl vs 3.5 mmol/L without NaCl, 95% CI: -0.50 to 0.30, p = 0.55), fasting glucose or AUC

conclusionsIn individuals post-RYGB without diabetes, sodium supplementation during a carbohydrate-rich meal did not substantially affect glucose homeostasis, although it appeared to reduce peak postprandial plasma glucose. Further studies are warranted to explore the clinical relevance of this effect.

Indexed as

Blood GlucoseDietary CarbohydratesGastric BypassObesity, MorbidSodium Chloride, DietaryAdultAgedCross-Over StudiesFemaleGlucagon-Like Peptide 1HomeostasisHumansInsulinMaleMiddle AgedPostprandial PeriodBlood GlucoseDietary CarbohydratesGlucagon-Like Peptide 1InsulinSodium Chloride, DietaryGlucoseInsulinRoux-en-Y gastric bypassSaltSodium

Identifiers

PMID41313432
PMCPMC12852143

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.