SynthesisNeurosurgical review2025
Efficacy of powdered vancomycin in the prophylaxis of surgical site infections in posterior thoracic and/or lumbar spine surgery: a systematic review of randomized clinical trials with meta-analysis.
Synthesis in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surgical site infections (SSIs) occur in 1-14% of spine surgeries, especially thoracic procedures, with methicillin-resistant Staphylococcus aureus (MRSA) as a primary pathogen. Due to antibiotic resistance concerns, powdered vancomycin application offers a promising alternative by providing high local concentrations with minimal systemic effects. Despite its potential, efficacy evidence remains controversial, with concerns about side effects and resistance development. This PRISMA-guided systematic review evaluates powdered vancomycin's effectiveness in preventing SSIs in posterior thoracic and lumbar spine surgeries through analysis of randomized clinical trials. This meta-analysis evaluated powdered vancomycin in preventing surgical site infections in posterior thoracic/lumbar spine surgeries using the PICO framework. The study included randomized trials comparing topical vancomycin to standard techniques, with searches conducted in PubMed, Cochrane Library, Web of Science, and Embase databases through 2024. Two independent reviewers performed study selection and data extraction. The analysis utilized RevMan
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.