ArticleGenome biology and evolution2025
Revisiting the Glucose Kinase Superfamily: From Origins to the Evolution of Metabolism.
Article in Genome biology and evolution, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The glucose kinase superfamily, which includes enzymes such as hexokinases and glucokinases, plays a central role in energy metabolism across all domains of life. This study explores their evolutionary origins, functional diversity, and adaptation to ecological niches, tracing their journey from early life forms to modern organisms. Recent advances reveal how these enzymes have diversified, with some retaining broad specificity, while others evolved high substrate specificity, reflecting the metabolic demands of their environments. By integrating phylogenetic, structural, and functional analyses, this work sheds light on the evolutionary pressures that shaped these enzymes and their role in metabolic innovation, not only deepening our understanding of life's biochemical evolution but also connecting ancient metabolic pathways to contemporary cellular processes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.