Evidence map›Paper›PMID 41313155›Full record

ArticleeLife2025

Human

Maribel Franco, Ricardo Gargini, Víctor M Barberá, Daniel Becerra, Miguel Saceda, Ana Carmena

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Frontiers in cell and developmental biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maribel FrancoInstituto de Neurociencias, Consejo Superior de Investigaciones Científicas/Universidad Miguel Hernández de Elche, Alicante, Spain.
Ricardo GarginiInstituto de Investigación Biomédicas I+12 and Pathology and Neurooncology Unit, Hospital Universitario 12 de Octubre, Madrid, Spain.
Víctor M BarberáUnidad de Investigación, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Hospital General Universitario de Elche, Elche, Spain.
Daniel BecerraInstituto de Neurociencias, Consejo Superior de Investigaciones Científicas/Universidad Miguel Hernández de Elche, Alicante, Spain.ORCID https://orcid.org/0009-0008-9076-9695
Miguel SacedaUnidad de Investigación, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO), Hospital General Universitario de Elche, Elche, Spain.
Ana CarmenaInstituto de Neurociencias, Consejo Superior de Investigaciones Científicas/Universidad Miguel Hernández de Elche, Alicante, Spain.ORCID https://orcid.org/0000-0003-1855-7934

Funding

Generalitat Valenciana Prometeo/2021/052Instituto de Salud Carlos III PI22/00824Instituto de Salud Carlos III PI22/01171Ministerio de Ciencia e Innovación PID2021-123196NB-100Ministerio de Ciencia, Innovación y Universidades PGC2018-097093-B-100
6 · The paper itself

Abstract

Asymmetric cell division (ACD) is a fundamental process to balance cell proliferation and differentiation during development and in the adult. Cancer stem cells (CSCs), a very small but highly malignant population within many human tumors, are able to provide differentiated progeny by ACD that contribute to the intratumoral heterogeneity, as well as to proliferate without control by symmetric, self-renewing divisions. Thus, ACD dysregulation in CSCs could trigger cancer progression. Here, we consistently find low expression levels of

Indexed as

Asymmetric Cell DivisionBrain NeoplasmsGlioblastomaNeoplastic Stem Cellsrap GTP-Binding ProteinsAnimalsCell ProliferationDrosophila ProteinsHumansDrosophila Proteinsrap GTP-Binding Proteinsasymmetric stem cell divisioncancer biologycell biologyD. melanogasterDrosophilaglioblastoma neurosphere culturesglioblastoma stem cellshumanhuman RAP2A

Identifiers

PMID41313155
PMCPMC12662630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.