Observational studyMicrobiology spectrum2026
A post-implementation evaluation of BioFire FilmArray Meningitis/Encephalitis panel for pathogen detection in cerebrospinal fluid with a special focus on clinical significance of HHV-6.
Observational study in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Denominator and Workflow Dependence of Age-Specific Viral Detection in Cerebrospinal Fluid.Pathogens (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Syndromic molecular testing for the diagnosis of infections has been advantageous given high sensitivity and rapid diagnostics; however, challenges remain with appropriate interpretation. A post-implementation evaluation of the cerebrospinal fluid (CSF) BioMerieux BioFire FilmArray Meningitis/Encephalitis panel in an adult and pediatric population was performed. The aims were to assess the prevalence and epidemiology of all targets and to correlate laboratory parameters with results from human herpesvirus 6 (HHV-6) detection in CSF to identify opportunities to apply diagnostic stewardship. A retrospective observational study was conducted on CSF Nucleic Acid Amplification Test (NAAT) results performed at a referral laboratory in Australia between 19 March 2022 and 31 July 2023. Laboratory data were extracted, with additional clinical data obtained for the HHV-6 positive subcohort. Of 1,490 CSF specimens identified, 287 (19.3%) had a positive NAAT. Non-neonate CSF specimens with white cell count (WCC) above the normal range had a higher proportion of NAAT-positive rates (35.3%) compared to those with WCC < 5 × 10 IMPORTANCE: Utilization of molecular testing methods enables rapid and high-sensitivity diagnostics, which can have significant impacts upon clinical outcomes in meningitis and encephalitis. However, challenges remain with the interpretation of results when syndromic panels are used, such as with the detection of human herpesvirus 6 (HHV-6) in cerebrospinal fluid (CSF). This study aimed to evaluate the BioMerieux BioFire FilmArray Meningitis/Encephalitis panel for the detection of pathogens in CSF in an adult and pediatric population. Data demonstrated that performing CSF nucleic acid amplification testing without diagnostic stewardship strategies in place can be associated with increased detection of potential bystander pathogens, including HHV-6.
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