Evidence map›Paper›PMID 41313023›Full record

ArticleMicrobiology spectrum2026

Comparative volatilomics identifies ubiquitous sulfur compounds inhibiting the fungal pathogen

Delphine Adam, Djulia Bensaada, Nudzejma Stulanovic, Jean-François Focant, Pierre-Hugues Stefanuto, Sébastien Rigali

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Delphine AdamInBioS-Center for Protein Engineering, Institut de Chimie B6a, University of Liège, Liège, Belgium.ORCID 0009-0008-5194-7671
Djulia BensaadaMolecular System - Organic Biological Analytical Chemistry Group, University of Liège, Liège, Belgium.ORCID 0009-0004-0973-6716
Nudzejma StulanovicInBioS-Center for Protein Engineering, Institut de Chimie B6a, University of Liège, Liège, Belgium.ORCID 0000-0003-3243-4973
Jean-François FocantMolecular System - Organic Biological Analytical Chemistry Group, University of Liège, Liège, Belgium.ORCID 0000-0001-8075-2920
Pierre-Hugues StefanutoMolecular System - Organic Biological Analytical Chemistry Group, University of Liège, Liège, Belgium.ORCID 0000-0002-1224-8869
Sébastien RigaliInBioS-Center for Protein Engineering, Institut de Chimie B6a, University of Liège, Liège, Belgium.ORCID 0000-0003-4022-7325

Funding

Fondation Léon FrédéricqFonds De La Recherche Scientifique - FNRS FNRS-PDR T.0195.23Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture FRIA 1.E.054.17-19-FonctFonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture FRIA 1.E116.21XL-Chem Graduate School of Research (XL-Chem) ANR-18-EURE-0020 XL CHEM
6 · The paper itself

Abstract

Members of the phylum Actinomycetota, particularly IMPORTANCE: Our findings suggest that antifungal activity against human pathogens may arise from common metabolic pathways shared across diverse microbes rather than from unique biosynthetic systems. Because dimethyl disulfide and dimethyl trisulfide can also be generated through microbial and dietary sulfur metabolism, it is plausible that the human microbiome may produce similar volatiles depending on diet composition, particularly following consumption of sulfur-rich foods. This study, therefore, underscores the critical influence of culture conditions on revealing bioactive volatile production and opens intriguing perspectives on the ecological and physiological roles of ubiquitous microbial metabolites in regulating fungal colonization and microbiome-host interactions.

Indexed as

Antifungal AgentsSulfur CompoundsVolatile Organic CompoundsCystic FibrosisHumansPhylogenyStreptomycesAntifungal AgentsSulfur CompoundsVolatile Organic Compoundsantifungal compoundsAspergillus fumigatusCandida albicanschronic granulomatous diseasecystic fibrosissulfur-containing volatile compoundsvolatilomics

Identifiers

PMID41313023
PMCPMC12772349

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.