Evidence map›Paper›PMID 41313007›Full record

ArticlemBio2026

Commensal-derived short-chain fatty acids disrupt lipid membrane homeostasis in

Joshua R Fletcher, Lisa A Hansen, Julia R Hoyser, Allison E Hanna, Richard Martinez, Christian D Freeman, Niall T Thorns, Mitchell R Penningroth, Alex R Villarreal, Grace A Vogt and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Functional CFTR may be required for Prevotella melaninogenica regulation of epithelial cell defense against Staphylococcus aureus.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Joshua R FletcherDepartment of Microbiology & Immunology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-0723-3195
Lisa A HansenDepartment of Microbiology & Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA.
Julia R HoyserDepartment of Microbiology & Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA.
Allison E HannaDepartment of Microbiology & Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA.
Richard MartinezDepartment of Microbiology & Immunology, University of Minnesota, Minneapolis, Minnesota, USA.
Christian D FreemanDepartment of Chemistry, University of Georgia, Athens, Georgia, USA.
Niall T ThornsDepartment of Microbiology & Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA.
Mitchell R PenningrothDepartment of Microbiology & Immunology, University of Minnesota, Minneapolis, Minnesota, USA.
Alex R VillarrealDepartment of Microbiology & Immunology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0003-3820-2153
Grace A VogtDepartment of Microbiology & Immunology, University of Minnesota, Minneapolis, Minnesota, USA.
Matthew A TylerDepartment of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA.
Kelly M HinesDepartment of Chemistry, University of Georgia, Athens, Georgia, USA.ORCID 0000-0001-9125-5268
Ryan C HunterDepartment of Microbiology & Immunology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0003-3841-1676

Funding

TRAINING-PULMONARY CELL &MOLECULAR BIOLOGY &PHYSIOLOGYT32HL007741 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI DUDLEY, R. ADAMS, INGBAR, DAVID H · 1994 to 2023
$13.9M
The role of anaerobic microbiota in cystic fibrosis airway disease trajectoryR01AI177613 · NIAID · UNIVERSITY OF MINNESOTA · PI Ryan Coulson Hunter · 2023 to 2026
$2.5M
Bacterial mucin degradation in cystic fibrosis airway disease.R01HL136919 · NHLBI · UNIVERSITY OF MINNESOTA · PI HUNTER, RYAN COULSON · 2017 to 2021
$2.1M
Impacts of host lipid composition on antimicrobial susceptibilities of Staphylococcus aureusR01AI173144 · NIAID · UNIVERSITY OF GEORGIA · PI Kelly M. Hines · 2023 to 2026
$1.8M
NHLBI NIH HHS R01 HL136919NHLBI NIH HHS T32 HL007741NIAID NIH HHS R01 AI173144NIAID NIH HHS R01 AI177613
6 · The paper itself

Abstract

The role of commensal anaerobic bacteria in chronic respiratory infections is unclear, yet they can exist in abundances comparable to canonical pathogens

Indexed as

Fatty Acids, VolatileHomeostasisMembrane LipidsStaphylococcus aureusHumansPseudomonas aeruginosaQuorum SensingStaphylococcal InfectionsFatty Acids, VolatileMembrane Lipidsanaerobesbranched-chain fatty acidslipidomicsshort-chain fatty acidsStaphylococcus aureus

Identifiers

PMID41313007
PMCPMC12802256

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.