Evidence map›Paper›PMID 41312994›Full record

ArticleAntimicrobial agents and chemotherapy2026

Synergistic activity of rifampicin and polymyxin B against intracellular Gram-negative ESKAPE pathogens involves bacterial membrane alterations and enhanced oxidative damages.

Vallo Varik, Gang Wang, George Kritikos, Manuel Banzhaf, Emilien Drouot, Alexandra Koumoutsi, Françoise Van Bambeke

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vallo Varik *Pharmacologie cellulaire et moléculaire, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.ORCID 0000-0001-6900-6986
Gang Wang *Pharmacologie cellulaire et moléculaire, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.ORCID 0009-0000-0228-0120
George KritikosEuropean Molecular Biology Laboratory, Heidelberg, Germany.ORCID 0000-0003-1434-5176
Manuel BanzhafNewcastle University Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.ORCID 0000-0002-4682-1037
Emilien DrouotPharmacologie cellulaire et moléculaire, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.
Alexandra KoumoutsiEuropean Molecular Biology Laboratory, Heidelberg, Germany.ORCID 0000-0001-8368-4193
Françoise Van BambekePharmacologie cellulaire et moléculaire, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.ORCID 0000-0002-0052-7991

Funding

Belgian Fonds de la Recherche Scientifique T.0189.16Belgian Fonds de la Recherche Scientifique (FRS-FNRS) T.0205.22China Scholarship Council noneEOS (Excellence of Science) program, Belgian FNRS-FRS O.0011.22EU Horizon Europe DIGIBIO project 101060066Joint Programming Initiative on Antimicrobial Resistance Co-ActionUKRI Future Leaders Fellowship MR/V027204/1
6 · The paper itself

Abstract

Antibiotic-resistant bacteria, particularly the ESKAPE (

Indexed as

Anti-Bacterial AgentsGram-Negative BacteriaPolymyxin BRifampinAcinetobacter baumanniiCell MembraneDrug Resistance, Multiple, BacterialDrug SynergismEnterobacterEnterococcus faeciumEscherichia coliHumansKlebsiella pneumoniaeMicrobial Sensitivity TestsOxidative StressPseudomonas aeruginosaAnti-Bacterial AgentsPolymyxin BRifampindrug-drug interactiondrug repurposingESKAPE pathogensGram-negative bacteriaintracellular infectionpolymyxin Brifampicin

Identifiers

PMID41312994
PMCPMC12777556

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.