Evidence map›Paper›PMID 41312955›Full record

ReviewArchives of endocrinology and metabolism2025

Subclinical primary aldosteronism.

Stéfanie Parisien-La Salle, Jenifer M Brown, Cheng Hsuan Tsai, Gregory L Hundemer, Anand Vaidya

Abstract readReview
In one paragraph

Review in Archives of endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Stéfanie Parisien-La SalleCenter for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.ORCID 0000-0001-5960-4181
Jenifer M BrownCenter for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.ORCID 0000-0002-6647-639X
Cheng Hsuan TsaiCenter for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.ORCID 0000-0003-2859-5117
Gregory L HundemerDepartment of Medicine, Division of Nephrology, University of Ottawa, Ottawa, ON, Canada.ORCID 0000-0003-3559-3531
Anand VaidyaCenter for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.ORCID 0000-0002-0314-9252

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary aldosteronism (PA) is a major contributor to hypertension and cardiovascular disease. Subclinical PA, a preclinical or early manifestation of PA, has been identified in individuals with normal blood pressure and in those with mild hypertension without signs or symptoms of overt PA, using evidence from histopathology, hormonal biochemistry, proteomic, and genetic studies. Longitudinal studies have shown that subclinical PA increases the risk for developing incident hypertension, adverse cardiovascular remodeling, major adverse cardiovascular events, and chronic kidney disease. Given the clinical relevance of subclinical PA on the pathogenesis of cardiorenal disease, future studies should focus on methods to enhance early detection and assessment of the impact of early aldosterone-directed interventions for preventing adverse clinical outcomes.

Indexed as

HyperaldosteronismAldosteroneAsymptomatic DiseasesCardiovascular DiseasesHumansHypertensionRenal Insufficiency, ChronicAldosteroneadrenalAldosteroneprimary aldosteronismreninsubclinical primary aldosteronism

Identifiers

PMID41312955
PMCPMC12668193

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.