Evidence map›Paper›PMID 41312950›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2025

Modification of Gold Nanoparticles Provides Antioxidant and Anti-Tumor Properties.

Ali G Al-Dulimi, Samah Ali Al Lateef, Mustafa Hadi, Zina F H Al-Obaidi, Ahmed Flayyih Hasan, Hany M El-Wahsh

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Article in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ali G Al-DulimiCollege of Dentistry, University of Bilad Alrafidain, Diyala, 32001, Iraq.
Samah Ali Al LateefCollege of Science, Forensic Evidence, Al-Nahrain University, Baghdad, Iraq.
Mustafa HadiBiotechnology Research Center, Al-Nahrain University, Baghdad, Iraq.
Zina F H Al-ObaidiDepartment of Medical and Molecular Biotechnology, College of Biotechnology, Al-Nahrain University, Baghdad, Iraq.
Ahmed Flayyih HasanBiotechnology Research Center, Al-Nahrain University, Baghdad, Iraq.
Hany M El-WahshMarine Biology Department, King Abdulaziz University, Faculty of Marine Sciences, King Abdulaziz University, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMetal nanoparticles such as gold (Au NPs) are less poisonous than those used in drug transporters through several features, making them predominantly suitable for biological or pharmacological requirements. MATERIALS AND

methodsmanufactured Au-NPs-PEG, then followed by encapsulation with SH-PEG-COOH to create a conjugate, which was validated via X-Ray diffraction analysis (XRD), in addition to Field-emission scanning electron microscopy (FE-SEM). The effectiveness of the Au NPs and Au NPs-PEG to MCF-7 (a cell line from human breast cancer) was estimated using antioxidant activity and clonogenicity assays.

resultsThe results showed that the produced nanoparticles were generally sphere-shaped with a smooth surface, with sizes of about 20.57 ± 2.51 nm and 29.14 ± 3.31 nm for gold nanoparticles and gold nanoparticles -PEG conjugate, respectively. Investigations were conducted into the antioxidant capacity of Au NPs and Au NPs-PEG conjugate against DPPH, and the Au NPs-PEG conjugate showed the maximum radical scavenging (84.661.79%) in concentration-dependent increments. A clonogenic survival assay investigated Au NPs and Au NPs-PEG conjugates for cytotoxicity against the MCF-7 cell line. Au NPs conjugate lowered the number of MCF-7 clones more effectively than the control.

conclusionsThe generated Au NPs-PEG had a strong cytotoxic effect on the MCF-7 cells, accelerating cell death and enhancing cellular absorption of the chemical.

Indexed as

Antineoplastic AgentsAntioxidantsBreast NeoplasmsGoldMetal NanoparticlesCell ProliferationCell SurvivalFemaleHumansMCF-7 CellsPolyethylene GlycolsTumor Cells, CulturedAntineoplastic AgentsAntioxidantsGoldPolyethylene GlycolsAntioxidantanti-tumorKeywords: Gold nanoparticlesPEG

Identifiers

PMID41312950
PMCPMC12948176

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.