ArticleAsian Pacific journal of cancer prevention : APJCP2025
Eco-friendly Extraction of Proanthocyanidin-Rich Compounds from Tamarind Seed Husk and Their Anti-Liver Cancer Activity.
Article in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to optimize the green extraction of phenolic compounds from TSH and evaluate their antioxidant and anti-liver cancer activities.
methodsTSH was extracted using 60% ethanol and distilled water in different temperatures using a 2-level factorial design as the variables, followed by tray drying. Extracts were analyzed for total phenolic content (TPC) using Folin-Ciocalteu reagent as the response and DPPH radical scavenging assay. Oligomeric proanthocyanidins were characterized by high performance liquid chromatography (HPLC) and liquid chromatography tandem mass spectrometry (LC-ESI-QTOF-MS/MS). Cytotoxicity and antimigratory effects on HepG2 cells were assessed using sulforhodamine B (SRB) and wound healing assays.
resultThe optimal model equation was TPC = 0.9 - 0.0064A + 0.0059B + (2.61 × 10-5)AB. Although the ethanolic extract had higher total phenolic content, but the water extract showed stronger antioxidant activity and exhibited significantly stronger cytotoxic activity (IC50 at 72 hours: 44.1±0.9 µg/mL) than ethanolic extract (408.3±9.8 µg/mL) in a time- and dose-dependent manner. Migration of HepG2 cells was also significantly inhibited by the water extract in a dose-dependent manner.
conclusionThe water extract of TSH may serve as a promising candidate for functional ingredient development and natural anti-liver cancer applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.