Evidence map›Paper›PMID 41312937›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2025

Post-Transplant Infections in Multiple Myeloma and Lymphoma: Early Vulnerabilities and Long-Term Risks in ASCT Recipients.

Muchlis Achsan Udji Sofro, Mila Astrilia, Galih Prakasa Adhyatma, Arcita Hanjani Pramudita, Daniel Rizky, Budi Setiawan, Eko Adhi Pangarsa, Damai Santosa, Mika L Tobing, Suyono Suyono and 1 more

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Article in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Muchlis Achsan Udji SofroInfectious Diseases and Tropical Infection Division, Department of Internal Medicine, Faculty of Medicine, Diponegoro University, RSUP Dr. Kariadi Semarang, Indonesia.
Mila AstriliaInternal Medicine Resident, Department of Internal Medicine, Diponegoro University, RSUP Dr. Kariadi Semarang, Indonesia.
Galih Prakasa AdhyatmaFaculty Medicine, Muhammadiyah University of Semarang, Indonesia.
Arcita Hanjani PramuditaResearch affiliates at Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
Daniel RizkyHematology and Medical Oncology Division, Department of Internal Medicine, Faculty of Medicine, Diponegoro University, RSUP Dr. Kariadi Semarang, Indonesia.
Budi SetiawanHematology and Medical Oncology Division, Department of Internal Medicine, Faculty of Medicine, Diponegoro University, RSUP Dr. Kariadi Semarang, Indonesia.
Eko Adhi PangarsaHematology and Medical Oncology Division, Department of Internal Medicine, Faculty of Medicine, Diponegoro University, RSUP Dr. Kariadi Semarang, Indonesia.
Damai SantosaHematology and Medical Oncology Division, Department of Internal Medicine, Faculty of Medicine, Diponegoro University, RSUP Dr. Kariadi Semarang, Indonesia.ORCID 0000-0002-6093-5049
Mika L TobingHematology and Medical Oncology Division, Department of Internal Medicine, Faculty of Medicine, Diponegoro University, RSUP Dr. Kariadi Semarang, Indonesia.
Suyono SuyonoHematology and Medical Oncology Division, Department of Internal Medicine, Faculty of Medicine, Diponegoro University, RSUP Dr. Kariadi Semarang, Indonesia.
Catharina SuhartiHematology and Medical Oncology Division, Department of Internal Medicine, Faculty of Medicine, Diponegoro University, RSUP Dr. Kariadi Semarang, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with multiple myeloma (MM) and lymphoma undergoing autologous stem cell transplantation (ASCT) are at a higher risk of infection leading to increased morbidity and mortality. This study aims to analyze the infection patterns and outcomes in this population.

methodsA retrospective, descriptive study was conducted at Dr. Kariadi General Hospital, Semarang, Indonesia, involving 28 patients diagnosed with MM and lymphoma who underwent ASCT from January 2013 to May 2023. Data were collected from medical records and phone interviews. Infection patterns, bacterial pathogens, and outcomes were analyzed.

resultsOf the 28 patients, 75% experienced post-ASCT infections. Infections occurred predominantly in the first 10 days post-transplant, with 85% of infections occurring during this period. Six patients experienced multiple infection episodes. Blood cultures revealed 52% Gram-positive and 29% Gram-negative bacterial infections. Three patients (14%) died within 28 days post-transplant, though these deaths were attributed to non-infectious causes, including pulmonary edema and hemorrhagic stroke. Two patients developed late-onset infections occuring more than 300 days post-transplant.

conclusionsInfections remain a significant complication following ASCT in MM and lymphoma patients, particularly within the early post-transplant period. Gram-positive bacteria, especially Staphylococcus species, were the predominant pathogens identified.

Indexed as

Bacterial InfectionsHematopoietic Stem Cell TransplantationLymphomaMultiple MyelomaAdultAgedFemaleFollow-Up StudiesHumansIndonesiaMaleMiddle AgedPrognosisRetrospective StudiesRisk FactorsTransplantation, AutologousAutologous Stem Cell TransplantationInfectionsLymphomamultiple myelomaPost-transplant complications

Identifiers

PMID41312937
PMCPMC12936130

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