ArticleAsian Pacific journal of cancer prevention : APJCP2025
Perioperative Thrombocytosis as a Predictor of Long-Term Survival in Colorectal Cancer Patients: A Retrospective Cohort Study.
Article in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- The molecular mechanisms of platelets in tumor invasion and metastasis: a controversial role.Cancer biology & therapy · 2026Review
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Abstract
backgroundColorectal cancer (CRC) is one of the leading causes of cancer-related death globally. Thrombocytosis, or increased platelet count, has been identified as a poor prognostic factor in various cancers, including CRC. This study aimed to investigate the relationship between preoperative and postoperative thrombocytosis and the survival rate of CRC patients.
methodsThis retrospective cohort study enrolled 160 CRC patients who underwent surgery. Clinical data on preoperative and postoperative platelet counts, as well as survival rates, were collected from medical records. Thrombocytosis was defined as platelet levels exceeding 400 × 109/L. Survival analysis was performed using the Kaplan-Meier method, and relationships between variables were assessed with the Chi-squared test.
resultsA total of 54 (33.7%) of patients experienced preoperative thrombocytosis and 23.1% experienced postoperative thrombocytosis. The 5-year cumulative survival rate of 160 CRC patients was 27.83 ± 16.97 months, with a mortality rate of 92.5%. There was a significant relationship between thrombocytosis and cancer stage (p=0.001) and tumor location (p=0.003), where patients with thrombocytosis were more likely to present with late-stage tumors and tumors of the rectum. Kaplan-Meier analysis showed that patients with thrombocytosis, especially those with postoperative thrombocytosis, had a significantly lower survival rate than patients without thrombocytosis.
conclusionThrombocytosis, particularly after surgery, is an important predictor of poor prognosis in CRC patients. Monitoring and managing thrombocytosis should be considered in efforts to improve patient survival.
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