Observational studyCancer medicine2025
Associations Between Ostomy Creation and Health-Related Quality of Life in Colorectal Cancer Patients: A Longitudinal Observational Study.
Observational study in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Associations Between Ostomy Creation and Health-Related Quality of Life in Colorectal Cancer Patients: A Longitudinal Observational Study.Cancer medicine · 2025Observational
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundMany colorectal cancer (CRC) patients require stoma creation following surgical resection. Stomas can significantly impact health-related quality of life (HRQOL), yet prospective longitudinal studies exploring this are limited. This study aimed to assess HRQOL among CRC patients comparing between those with and without stomas, and examining differences between subgroups.
methodsThis prospective longitudinal study was conducted across five hospitals in Singapore from 2018 to 2023. CRC patients undergoing surgical resection were assessed at six timepoints from diagnosis to 12-month post-surgery. HRQOL was measured using the EORTC QLQ-C30 instrument. Multilevel mixed-effects tobit regression models were used to evaluate HRQOL changes over time and identify significant predictors of HRQOL outcomes.
resultsAmong 240 patients, 91 (37.9%) underwent stoma creation. Stoma patients reported significantly poorer HRQOL, particularly in global health status and functional domains at 1 month post-surgery, which persisted into the 3-month timepoint for role (77.43 vs. 86.67, p < 0.05) and emotional (82.11 vs. 90.20, p < 0.05) functioning. Stoma creation predicted reduced physical (β = -10.39, 95% CI: -15.80, -4.97) and role functioning (β = -12.24, 95% CI: -24.38, -0.10). Subgroup differences were mostly non-significant, except for consistently lower cognitive functioning scores in patients with permanent as opposed to temporary stomas (e.g., 1 month; 73.08 vs. 91.19, p < 0.025).
conclusionsStoma creation adversely affects HRQOL, particularly in the early postoperative period. Comprehensive post-surgical support addressing physical, psychological, and financial challenges may be crucial to enhance overall HRQOL for stoma patients. Further research should explore tailored support strategies and the effect of early versus delayed stoma closure on HRQOL outcomes.
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