Evidence map›Paper›PMID 41312650›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2026

Evaluation of a New Methylimidazole-Containing Thiosemicarbazone as a Cu

Barbara Marinho Barbosa, Charlène Esmieu, Antal Galvácsi, Mariana Viana Costa, Adèle Brison, Sonia M Ladeira, Jade de Oliveira, Csilla Kállay, Christelle Hureau, Nicolás A Rey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The Effect of CuACS chemical neuroscience · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Barbara Marinho BarbosaDepartment of Chemistry, Pontifical Catholic University of Rio de Janeiro (PUC-Rio), Rio de Janeiro, Brazil.ORCID https://orcid.org/0009-0008-1203-7237
Charlène EsmieuLaboratoire De Chimie de Coordination (LCC), CNRS, University of Toulouse, Toulouse, France.ORCID https://orcid.org/0000-0003-1412-033X
Antal GalvácsiDepartment of Inorganic and Analytical Chemistry, University of Debrecen, Debrecen, Hungary.ORCID https://orcid.org/0009-0004-9672-0850
Mariana Viana CostaDepartment of Biochemistry, Basic Health Sciences Institute, Federal University of Rio Grande Do Sul, Rio Grande do Sul, Brazil.ORCID https://orcid.org/0009-0008-2455-9833
Adèle BrisonLaboratoire De Chimie de Coordination (LCC), CNRS, University of Toulouse, Toulouse, France.
Sonia M LadeiraLaboratoire De Chimie de Coordination (LCC), CNRS, University of Toulouse, Toulouse, France.ORCID https://orcid.org/0009-0004-2446-6697
Jade de OliveiraDepartment of Biochemistry, Basic Health Sciences Institute, Federal University of Rio Grande Do Sul, Rio Grande do Sul, Brazil.ORCID https://orcid.org/0000-0003-1454-2866
Csilla KállayDepartment of Inorganic and Analytical Chemistry, University of Debrecen, Debrecen, Hungary.ORCID https://orcid.org/0000-0002-3910-2499
Christelle HureauLaboratoire De Chimie de Coordination (LCC), CNRS, University of Toulouse, Toulouse, France.ORCID https://orcid.org/0000-0003-3339-0239
Nicolás A ReyDepartment of Chemistry, Pontifical Catholic University of Rio de Janeiro (PUC-Rio), Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-0624-7560

Funding

ANR project Copperation ANR-20-CE07-0009Conselho Nacional de Desenvolvimento Científico e Tecnológico, BrazilCoordenação de Aperfeiçoamento de Pessoal de Nível Superior 88881.878977/2023-01Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de JaneiroFundação de Amparo à Pesquisa do Estado do Rio Grande do Sul 24/2551-0001978-2
6 · The paper itself

Abstract

The binding of copper ions to amyloid-β (Aβ) peptide leads to reactive oxygen species (ROS) formation and toxic soluble oligomers, contributing to oxidative stress in Alzheimer's disease (AD). Thus, studying compounds with moderate copper affinity is a promising strategy to prevent its interaction with Aβ and reduce toxicity. Here, we evaluated a new tri-coordinating thiosemicarbazone (HXE) with chelating properties to regulate cuprotoxicity in AD. The ligand was nontoxic against HT-22 hippocampal neuronal cells and bound Cu

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesChelating AgentsCopperImidazolesThiosemicarbazonesAnimalsCoordination ComplexesHumansLigandsMiceOxidative StressReactive Oxygen SpeciesAmyloid beta-PeptidesChelating AgentsCoordination ComplexesCopperImidazolesLigandsReactive Oxygen SpeciesThiosemicarbazonesAÎ2 aggregationAlzheimer's diseaseCopperROSThiosemicarbazone

Identifiers

PMID41312650
PMCPMC12759177

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.