Evidence map›Paper›PMID 41312645›Full record

ArticleNucleic acids research2026

Meta-virus resource (MetaVR): expanding the frontiers of viral diversity with 24 million uncultivated virus genomes.

Mateus B Fiamenghi, Antonio Pedro Camargo, Iro N Chasapi, Fotis A Baltoumas, Simon Roux, Artyom A Egorov, Eleni Aplakidou, Eric Olo Ndela, Yumary M Vasquez, I-Min A Chen and 9 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. A look into the virosphere of clouds: A world yet to be explored.Current research in microbial sciences · 2026
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Mateus B FiamenghiDOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.ORCID 0000-0003-4535-8594
Antonio Pedro CamargoDOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.ORCID 0000-0003-3913-2484
Iro N ChasapiInstitute for Fundamental Biomedical Research, BSRC "Alexander Fleming", Vari 16672, Greece.
Fotis A BaltoumasInstitute for Fundamental Biomedical Research, BSRC "Alexander Fleming", Vari 16672, Greece.ORCID 0000-0002-2870-2931
Simon RouxDOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.ORCID 0000-0002-5831-5895
Artyom A EgorovDepartment of Experimental Medical Science, Lund University, Lund, SE-221 00, Sweden.ORCID 0000-0001-5578-5384
Eleni AplakidouInstitute for Fundamental Biomedical Research, BSRC "Alexander Fleming", Vari 16672, Greece.
Eric Olo NdelaDOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.
Yumary M VasquezDOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.
I-Min A ChenDOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.ORCID 0000-0003-2026-9798
Krishna PalaniappanDOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.
T B K ReddyDOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.ORCID 0000-0002-0871-5567
Supratim MukherjeeDOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.ORCID 0000-0002-6322-2271
Natalia N IvanovaDOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.
Frederik SchulzDOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.ORCID 0000-0002-4932-4677
Tanja WoykeDOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.ORCID 0000-0002-9485-5637
Emiley A Eloe-FadroshDOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.ORCID 0000-0002-8162-1276
Georgios A PavlopoulosInstitute for Fundamental Biomedical Research, BSRC "Alexander Fleming", Vari 16672, Greece.ORCID 0000-0002-4577-8276
Nikos C KyrpidesDOE Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States.ORCID 0000-0002-6131-0462

Funding

Advanced analytics for uncovering virus dynamics and functional potentialU01DE034196 · NIDCR · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Nikos C Kyrpides · 2024 to 2026
$2.8M
BER's Genomic Sciences Program FWP 70880Hellenic Foundation for Research and InnovationNatural Sciences, Medicine and Technology 45379NIDCR NIH HHS U01 DE034196NIH HHS 1U01DE034196-01Royal Physiographic Society of LundUS DOE DE-AC02-05CH11231
6 · The paper itself

Abstract

Viruses are ubiquitous in all environments and impact host metabolism, evolution, and ecology, although our knowledge of their biodiversity is still extremely limited. Viral diversity from genomic and metagenomic datasets has led to an explosion of uncultivated virus genomes (UViGs) and the development of specialized databases to catalog this viral diversity, though many lack comprehensive integration. Here, we introduce meta-virus resource (MetaVR), the successor of the IMG/VR database, designed to overcome previous limitations such as large-scale querying and programmatic access. Drawing on the increase of publicly available genomes and metagenomes, MetaVR significantly expands viral diversity, now comprising 24,435,662 UViGs, a 57.6% increase from its predecessor, organized into over 12 million viral operational taxonomic units. Key enhancements include the integration of curated eukaryotic host information, the integration of protein clusters and predicted structures for comparative studies, and an API for programmatic data access. Furthermore, MetaVR features an updated taxonomic framework based on ICTV release 39, assignment to Baltimore classes, and enhanced host assignment through novel computational tools like iPHoP. These advancements position MetaVR as a unique resource for exploring viral diversity, evolution, and host interactions across diverse environments. MetaVR can be freely accessed at https://www.meta-virome.org/.

Indexed as

Databases, GeneticGenome, ViralVirusesBiodiversityGenetic VariationMetagenomeMetagenomicsPhylogenySoftware

Identifiers

PMID41312645
PMCPMC12807716

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.