Evidence map›Paper›PMID 41312629›Full record

ReviewJournal of gynecologic oncology2026

The future of gynecologic oncologic surgery: a narrative review of current surgical trials.

Stefano Fucina, Claudio Reato, Anna Del Fabro, Tommaso Occhiali, Emilio Lucia, Luca Martella, Michele Bartoletti, Gustavo Baldassarre, Nicolò Clemente, Vincenzo Canzonieri and 4 more

Abstract readReview
In one paragraph

Review in Journal of gynecologic oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Stefano FucinaGynecological Oncology Unit, CRO Aviano, National Cancer Institute, IRCCS, Aviano, Italy.ORCID 0009-0001-2374-7030
Claudio ReatoGynecological Oncology Unit, CRO Aviano, National Cancer Institute, IRCCS, Aviano, Italy.ORCID 0000-0002-7439-8029
Anna Del FabroGynecological Oncology Unit, CRO Aviano, National Cancer Institute, IRCCS, Aviano, Italy.ORCID 0000-0002-6403-7705
Tommaso OcchialiGynecological Oncology Unit, CRO Aviano, National Cancer Institute, IRCCS, Aviano, Italy.ORCID 0000-0002-0316-1008
Emilio LuciaGynecological Oncology Unit, CRO Aviano, National Cancer Institute, IRCCS, Aviano, Italy.ORCID 0000-0001-6882-5613
Luca MartellaGynecological Oncology Unit, CRO Aviano, National Cancer Institute, IRCCS, Aviano, Italy.ORCID 0000-0002-2058-1469
Michele BartolettiMedical Oncology and Cancer Prevention, CRO Aviano, National Cancer Institute, IRCCS, Aviano, Italy.ORCID 0000-0002-9631-5693
Gustavo BaldassarreMolecular Oncology Unit, CRO Aviano, National Cancer Institute, IRCCS, Aviano, Italy.ORCID 0000-0002-9750-8825
Nicolò ClementeGynecological Oncology Unit, CRO Aviano, National Cancer Institute, IRCCS, Aviano, Italy.ORCID 0000-0003-2748-3041
Vincenzo CanzonieriPathology Unit, CRO Aviano, National Cancer Institute, IRCCS, Aviano, Italy.ORCID 0000-0001-6010-0976
Margherita PolettoClinical Trial Unit, CRO Aviano, National Cancer Institute, IRCCS, Aviano, Italy.ORCID 0009-0007-0776-2138
Umberto Leone Roberti MaggioreGynecologic Oncology Unit, Fondazione Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) Istituto Nazionale dei Tumori, Milan, Italy.ORCID 0000-0002-3744-2668
Francesco RaspagliesiGynecologic Oncology Unit, Fondazione Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) Istituto Nazionale dei Tumori, Milan, Italy.ORCID 0000-0001-8953-1657
Antonino DittoGynecological Oncology Unit, CRO Aviano, National Cancer Institute, IRCCS, Aviano, Italy.ORCID 0000-0002-5684-8225

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent advances in gynecologic oncology have driven a paradigm shift toward less invasive, more personalized surgical approaches. This narrative review critically examines key ongoing international trials investigating innovative surgical strategies across vulvar, cervical, ovarian, and endometrial cancers, with a focus on improving oncologic outcomes while minimizing morbidity. In vulvar cancer, trials are exploring the use of neoadjuvant chemotherapy and the replacement of inguinofemoral lymphadenectomy with chemoradiation in selected patients. For cervical cancer, large multicenter randomized trials are evaluating the oncologic safety of minimally invasive hysterectomy, surgical staging for para-aortic disease, and robotic-assisted surgery. In the contest of ovarian cancer, randomized trials are assessing the role of lymphadenectomy in early-stage disease, the optimal timing of cytoreductive surgery (primary versus interval), and the potential benefits of hyperthermic intraperitoneal chemotherapy, even in cases of platinum-resistant recurrence. For endometrial cancer, both observational and interventional studies are investigating sentinel lymph nodes mapping and robotic-assisted hysterectomy as alternatives to traditional staging procedures. Collectively, these trials underscore the growing importance of individualized treatment strategies guided by disease stage, histologic subtype, response to neoadjuvant therapy, and patient-specific factors. While minimally invasive techniques and surgical de-escalation appear promising for selected patient populations, critical questions remain regarding long-term oncologic safety, cost-effectiveness, and the consistency of practice across institutions. This narrative review synthesizes current evidence and outlines how the outcomes of these pivotal studies are expected to influence future guidelines in gynecologic cancer surgery.

Indexed as

Genital Neoplasms, FemaleGynecologic Surgical ProceduresCytoreduction Surgical ProceduresEndometrial NeoplasmsFemaleHumansLymph Node ExcisionNeoadjuvant TherapyOvarian NeoplasmsRandomized Controlled Trials as TopicRobotic Surgical ProceduresClinical TrialGynecologic NeoplasmsMinimally Invasive SurgerySurgery

Identifiers

PMID41312629
PMCPMC13009687

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.