Evidence map›Paper›PMID 41312616›Full record

ArticleHead & neck2026

Very Long-Term Follow-Up of Multidimensional Health-Related Quality of Life After Endoscopic Endonasal Surgery for Pituitary Adenomas: A Prospective Cohort Study.

Gonneke E Joustra, Nathalie F van Rhee, Marc C den Heijer, Astrid G W Korsten-Meijer, Robert A Feijen, György B Halmos, Jos M A Kuijlen, Karin M Vermeulen

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In one paragraph

Article in Head & neck, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gonneke E JoustraDepartment of Otorhinolaryngology-Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID 0000-0001-8171-0546
Nathalie F van RheeDepartment of Otorhinolaryngology-Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID 0009-0009-0457-9439
Marc C den HeijerDepartment of Otorhinolaryngology-Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID 0000-0002-0425-613X
Astrid G W Korsten-MeijerDepartment of Otorhinolaryngology-Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID 0000-0001-5094-7698
Robert A FeijenDepartment of Otorhinolaryngology-Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID 0000-0002-8568-0847
György B HalmosDepartment of Otorhinolaryngology-Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID 0000-0003-2460-2260
Jos M A KuijlenDepartment of Neurosurgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID 0000-0002-2907-5853
Karin M VermeulenDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID 0000-0001-9257-2791

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate postoperative health-related quality of life (HRQoL) for pituitary adenoma patients, multidimensional assessment is important. Available data is limited on long-term follow-up.

methodsProspectively, 52 nonfunctioning (NFA) and functioning (FA) pituitary adenoma patients were included. The Endoscopic Endonasal Sinus and Skull Base Surgery Questionnaire (EES-Q) was completed preoperatively and postoperatively (2 weeks, 3 months, 1 year, 8.5 years). Generalized estimating equations identified variables associated with HRQoL changes over time.

resultsPsychological (p = 0.006) and social HRQoL (p = 0.026) significantly improved after very long-term follow-up, while physical HRQoL and EES-Q scores normalized. Pre- and postoperatively, most inconveniences were reported in the social domain, with a noticeable difference between NFA and FA patients. Female gender negatively impacted physical HRQoL.

conclusionsEndoscopic endonasal surgery has no very long-term negative impact on HRQoL. Social functioning remained the most affected throughout follow-up. These results highlight the importance of this multidimensional HRQoL tool to improve patient-centered health care.

Indexed as

AdenomaEndoscopyPituitary NeoplasmsQuality of LifeAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesSurveys and QuestionnairesTime FactorsTreatment Outcomeanterior skull baseEndoscopic Endonasal Sinus and Skull Base Surgery Questionnaire (EES‐Q)endoscopic skull base surgerypatient‐reported outcome measurepituitary adenoma

Identifiers

PMID41312616
PMCPMC12972636

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.