Evidence map›Paper›PMID 41312588›Full record

ArticleAnatomical record (Hoboken, N.J. : 2007)2026

Rhythmic patterns in microglial cells within the circadian pineal gland from male rats.

Carlos L Freites, Martin Avila, Juan B Amiotti, Estela M Muñoz

Abstract read
In one paragraph

Article in Anatomical record (Hoboken, N.J. : 2007), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Carlos L FreitesLaboratory of Basic and Translational Neurobiology, Institute of Histology and Embryology of Mendoza (IHEM), National University of Cuyo (UNCuyo), National Scientific and Technical Research Council (CONICET), Mendoza, Argentina.ORCID https://orcid.org/0000-0002-5254-8145
Martin AvilaLaboratory of Basic and Translational Neurobiology, Institute of Histology and Embryology of Mendoza (IHEM), National University of Cuyo (UNCuyo), National Scientific and Technical Research Council (CONICET), Mendoza, Argentina.ORCID https://orcid.org/0000-0002-8666-2595
Juan B AmiottiLaboratory of Basic and Translational Neurobiology, Institute of Histology and Embryology of Mendoza (IHEM), National University of Cuyo (UNCuyo), National Scientific and Technical Research Council (CONICET), Mendoza, Argentina.
Estela M MuñozLaboratory of Basic and Translational Neurobiology, Institute of Histology and Embryology of Mendoza (IHEM), National University of Cuyo (UNCuyo), National Scientific and Technical Research Council (CONICET), Mendoza, Argentina.ORCID https://orcid.org/0000-0002-6701-1535

Funding

Fondo para la Investigación Científica y Tecnológica
6 · The paper itself

Abstract

Microglia, the innate immune cells of the brain, constitute a highly dynamic cell population that displays several functions influenced by the light:dark (L:D) cycle. Within the pineal gland (PG), a key organ of the circadian timing system, microglia actively participate in its development and homeostasis. However, little is known about their rhythmic features in this circadian organ. This study aimed to elucidate morphological and functional phenotypes of pineal microglia at two time points of the L:D cycle. We performed immunofluorescence staining and confocal microscopy on paraffin-embedded pineal sections from 3- and 18-month-old male Wistar rats, analyzing samples collected at midday (ZT6) and midnight (ZT18). In the 3-month-old PG, the density and spatial distribution of IBA1

Indexed as

Circadian RhythmMicrogliaPineal GlandAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticCalcium-Binding ProteinsCD68 MoleculeMaleMicrofilament ProteinsPAX6 Transcription FactorPhagocytosisRatsRats, WistarAif1 protein, ratAntigens, CDAntigens, Differentiation, MyelomonocyticCalcium-Binding ProteinsCD68 MoleculeCD68 protein, ratMicrofilament ProteinsPAX6 Transcription Factordaily rhythmsIBA1 positive cellsmicrogliamicroglial heterogeneitypineal gland

Identifiers

PMID41312588
PMCPMC13549259

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.