ArticleJournal of human nutrition and dietetics : the official journal of the British Dietetic Association2025
Nutrition Support Interventions for Children and Young People Treated for Osteosarcoma: A Scoping Review.
Article in Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Nutrition Support Interventions for Children and Young People Treated for Osteosarcoma: A Scoping Review.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveTo map evidence for nutrition interventions during osteosarcoma (OS) treatment for children and young people (CYP), identifying gaps to inform research for this predominantly adolescent group.
designScoping review following Joanna Briggs Institute methodology and PRISMA-ScR guidelines. DATA SOURCES: MEDLINE, EMBASE, CINAHL, EMCARE and CENTRAL were searched from inception to July 2025 using a three-step search strategy (pilot, full, reference screening). ELIGIBILITY CRITERIA: Studies were included if they assessed nutrition interventions in patients with OS aged < 25 years undergoing treatment. Mixed cancer cohorts were eligible if > 50% had OS or OS data were reported separately. EXCLUSIONS: qualitative studies, patients > 25 years, survivors, animal or in vitro studies. DATA EXTRACTION AND SYNTHESIS: Four reviewers independently screened studies. Data on methodologies, nutrition interventions, outcomes and study design limitations were extracted and reported descriptively.
resultsOf 7874 records retrieved, 15 studies (2001-2024) from 4 high- and 4 middle-income countries met inclusion, involving 964 participants (median age 13.3 years), including 5 conference abstracts. Ten studies addressed comprehensive nutrition support (macro- and micronutrients), mostly using retrospective cohorts, while five focused on micronutrients. Common interventions included parenteral nutrition (5/15) and early gastrostomy feeding (5/15). Ten peer-reviewed studies were fully characterised against the review objectives: six examined appetite stimulants, oral, enteral, and parenteral nutrition, or compared early versus reactive gastrostomy, reporting outcomes mainly via BMI Z-scores; four reported gastrostomy complications. Two case reports described thiamine deficiency, and two RCTs assessed magnesium and vitamin D supplementation in relation to febrile neutropenia and survival. Key limitations included small cohorts, incomplete intervention reporting and unvalidated outcome measures.
conclusionsResearch on nutrition interventions in CYP with OS is scarce, heterogeneous and methodologically weak. Large, prospective, multi-centre studies are urgently needed to establish evidence-based nutrition support strategies, valid outcome measures, and to examine the psychological impact of tube feeding for young people.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.