Evidence map›Paper›PMID 41312556›Full record

ReviewCanadian liver journal2025

The emerging role of liver transplantation in metastatic colorectal cancer.

Verena Rafael, Eric M Yoshida, Natasha Chandok

Abstract readReview
In one paragraph

Review in Canadian liver journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Verena RafaelMcMaster University, Hamilton, Ontario, Canada.
Eric M YoshidaDivision of Gastroenterology, University of British Columbia, Vancouver, British Columbia, Canada.
Natasha ChandokDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer has a high global prevalence and is one of the leading causes of cancer-related death. Approximately one quarter of patients with colorectal cancer will develop metastases, most commonly to the liver, with the majority of liver metastases being unresectable and carrying a poor prognosis. Initial results from trials examining liver transplantation as a potentially curative option for isolated liver metastases from colorectal cancer have yielded promising survival outcomes as compared with standard chemotherapy. However, many of the studies are small and non-randomized with highly selected patient cohorts. This treatment option also raises numerous ethical issues, most notably regarding its feasibility in settings with limited liver donor availability. In this review, current evidence examining outcomes following liver transplantation for liver-only colorectal metastases is outlined, along with details surrounding ongoing trials. Ethical and practical considerations surrounding its implementation as a treatment option are also explored.

Indexed as

colonic neoplasmscolorectalliver transplantation

Identifiers

PMID41312556
PMCPMC12657007

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.