Evidence map›Paper›PMID 41312528›Full record

ArticleNeurocomputing2025

Artificial intelligence without restriction surpassing human intelligence with probability one: Theoretical insight into secrets of the brain with AI twins of the brain.

Guang-Bin Huang, M Brandon Westover, Eng-King Tan, Haibo Wang, Dongshun Cui, Wei-Ying Ma, Tiantong Wang, Qi He, Haikun Wei, Ning Wang and 4 more

Abstract read
In one paragraph

Article in Neurocomputing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Hybrid fractal ConvXGBNet for brain tumor classification with log-cosh dice loss - cascaded V-Net based segmentation based on MRI images.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Guang-Bin HuangSchool of Automation, Southeast University, Nanjing, China.
M Brandon WestoverBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA.
Eng-King TanDepartment of Neurology, National Neuroscience Institute, Singapore.
Haibo WangResearch Centre of Big Data and Artificial Intelligence for Medicine, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Dongshun CuiMind PointEye, Singapore.
Wei-Ying MaInstitute for AI Industry Research, Tsinghua University, Beijing, China.
Tiantong WangCollege of Computing and Data Science, Nanyang Technological University, Singapore.
Qi HeResearch Centre of Big Data and Artificial Intelligence for Medicine, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Haikun WeiSchool of Automation, Southeast University, Nanjing, China.
Ning WangMind PointEye, Singapore.
Qiyuan TianSchool of Biomedical Engineering, Tsinghua University, Beijing, China.
Kwok-Yan LamCollege of Computing and Data Science, Nanyang Technological University, Singapore.
Xin YaoSchool of Data Science, Lingnan University, Hong Kong SAR, China.
Tien Yin WongSingapore Eye Research Institute, Singapore National Eye Centre, Singapore.

Funding

Data-Driven Sleep Biomarkers of Brain Health, Heart Health, and MortalityR01HL161253 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CLIFFORD, GARI DAVID, MIGNOT, EMMANUEL J · 2022 to 2025
$8.3M
Prospective Validation of Neurophysiologic Outcome Prediction in Acute Brain InjuryR01NS126282 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Aaron F Struck, Michael Brandon Westover · 2023 to 2026
$2.9M
Big Data and Deep Learning for the Interictal-Ictal-Injury ContiuumR01NS107291 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI WESTOVER, MICHAEL BRANDON · 2018 to 2022
$2.8M
Establishing a Brain Health Index from the Sleep ElectroencephalogramRF1NS120947 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CASH, SYDNEY S, THOMAS, ROBERT JOSEPH · 2021 to 2021
$2.4M
Establishing a Brain Health IndexR01NS120947 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CASH, SYDNEY S, THOMAS, ROBERT JOSEPH · 2024 to 2025
$1.6M
NHLBI NIH HHS R01 HL161253NINDS NIH HHS R01 NS107291NINDS NIH HHS R01 NS120947NINDS NIH HHS R01 NS126282NINDS NIH HHS RF1 NS120947
6 · The paper itself

Abstract

Artificial Intelligence (AI) has apparently become one of the most important techniques discovered by humans in history while the human brain is widely recognized as one of the most complex systems in the universe. One fundamental critical question which would affect human sustainability remains open: Will artificial intelligence (AI) evolve to surpass human intelligence in the future? This paper shows that in theory new AI twins with fresh cellular level of AI techniques for neuroscience could approximate the brain and its functioning systems (e.g. perception and cognition functions) with any expected small error and AI without restrictions could surpass human intelligence with probability one in the end. This paper indirectly proves the validity of the conjecture made by Frank Rosenblatt 70 years ago about the potential capabilities of AI, especially in the realm of artificial neural networks. This paper also gives the answer to the two widely discussed fundamental questions: 1) whether AI could have potentials of discovering new principles in nature; 2) whether error backpropagation (BP) algorithm commonly and efficiently used in tuning parameters in AI applications is also adopted in the brain. Intelligence is just one of fortuitous but sophisticated creations of the nature which has not been fully discovered. Like mathematics and physics, with no restrictions artificial intelligence would lead to a new subject with its self-contained systems and principles. We anticipate that this paper opens new doors for 1) AI twins and other AI techniques to be used in cellular level of efficient neuroscience dynamic analysis, functioning analysis of the brain and brain illness solutions; 2) new worldwide collaborative scheme for interdisciplinary teams concurrently working on and modelling different types of neurons and synapses and different level of functioning subsystems of the brain with AI techniques; 3) development of low energy of AI techniques with the aid of fundamental neuroscience properties; and 4) new controllable, explainable and safe AI techniques with reasoning capabilities of discovering principles in nature.

Indexed as

AI TwinsArtificial IntelligenceBack Propagation AlgorithmsCellular AIExtreme Learning MachinesNeuroscienceSpiking

Identifiers

PMID41312528
PMCPMC12656881

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.