SynthesisFrontiers in medicine2025
Efficacy and safety of esketamine in patients undergoing painless gastrointestinal endoscopy: a systematic review and meta-analysis of randomized controlled trials.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Esketamine vs. sufentanil for quality of recovery after outpatient gynecological surgery: a randomized clinical trial.Annals of medicine · 2026Trial
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Esketamine, an intravenous anesthetic with analgesic properties, is increasingly used as an adjunct in painless gastrointestinal endoscopy. This systematic review and meta-analysis evaluated the efficacy and safety of esketamine combined with sedatives for anesthesia in adults undergoing painless gastrointestinal endoscopy. Methods: Eight databases (PubMed, Web of Science, EMBASE, Cochrane Library, CNKI, Wanfang, VIP, SinoMed) were systematically searched from inception until April 20, 2025. Randomized controlled trials (RCTs) comparing esketamine adjunctive therapy against placebo/sedative-alone in adults (ASA I-II) were included. Primary efficacy outcomes were anesthesia onset time, recovery time, and sedative requirements. Primary safety outcomes included procedure-related adverse events, and postoperative complications. Data synthesis was performed by using Review Manager 5.4 software. Subgroup analyses examined sedative type and esketamine dose. Results: Fifteen RCTs ( Conclusion: Esketamine adjunctive therapy (optimal dose: 0.2-0.3 mg/kg) enhances sedation efficacy for painless gastrointestinal endoscopy by accelerating anesthesia onset, reducing sedative requirements, shortening recovery time, and decreasing intraoperative cardiorespiratory adverse events. Its primary safety concern is dose-dependent postoperative dizziness. Further large-scale, multinational trials are warranted to validate generalizability. Systematic review registration: CRD420251024070; https://www.crd.york.ac.uk/PROSPERO/view/CRD420251024070.
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