Evidence map›Paper›PMID 41312441›Full record

ArticleCurrent opinion in systems biology2025

Systems Virology at Scale.

Cameron D Griffiths, Andrew J Sweatt, Kevin A Janes

Abstract read
In one paragraph

Article in Current opinion in systems biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Cameron D GriffithsDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA.
Andrew J SweattDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA.
Kevin A JanesDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA.

Funding

In silico modeling of subcellular infection by diverse families of RNA virusR01AI186222 · NIAID · UNIVERSITY OF VIRGINIA · PI Kevin A Janes · 2024 to 2026
$1.6M
NIAID NIH HHS R01 AI186222
6 · The paper itself

Abstract

Today's subcellular and multicellular models of infection are poised to tackle bigger questions about virus-host interactions and the determinants of susceptibility. This opportunity comes from increased computing power, improved model architectures, and comprehensive datasets collected from virus-infected hosts. Here we summarize recent advances in viral modeling and data science that illustrate how systems models have successfully traversed increasing time-length scales, levels of detail, and ranges of biological context. The latest progress is encouraging, but recent findings just scratch the surface given how many different viruses exist or could someday emerge-the scale of the effort should align with the scale of the challenge. Abstraction of molecular and cellular networks by systems virology complements public-health models of viral transmission that are widely applied to human populations.

Indexed as

coronavirusdata scienceDifferential equationenterovirusflavivirus

Identifiers

PMID41312441
PMCPMC12652384

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.