ReviewPreventive medicine reports2025
Global insights into healthcare providers' knowledge, attitudes, practices, and concerns on pre-exposure prophylaxis: A systematic review and meta-analysis.
Review in Preventive medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Barriers, Facilitators, and Training Preferences for HIV PrEP Among Physicians in the State of Louisiana, USA.Journal of community health · 2026Article
- Knowledge, attitudes, and behavioural intention towards HIV pre-exposure prophylaxis among health science students in South Africa: cross-sectional study.Frontiers in public health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To systematically synthesize global evidence on healthcare providers' knowledge, attitudes, practices, and barriers toward HIV pre-exposure prophylaxis (PrEP. Methods: A systematic review and meta-analysis was conducted following a PROSPERO-registered protocol (CRD42025632990) and the PRISMA 2020 guidelines. Four electronic databases (PubMed, Web of Science, Cochrane Library, and Google Scholar) were systematically searched for literature published between May 1, 2014 and December 31, 2024. Study selection, guided by the PICoS framework, involved independent screening by two reviewers. Results: This review includes twenty seven observational studies, with a total of 8960 participants globally. The pooled knowledge of healthcare providers' regarding pre-exposure prophylaxis was 65 % (95 % CI, 60-70 %), the attitude rate was 78 % (95 % CI, 71-85 %), and the practice rate was 37 % (95 % CI, 32-41 %). Healthcare providers with a positive attitude were more likely to have good knowledge [OR = 2.28, (95 % CI, 1.52-3.04)]. Conclusion: Despite generally favorable attitudes and moderate knowledge, pre-exposure prophylaxis practice among healthcare providers remains low. Targeted interventions to improve training, resource access, and guideline awareness, along with strategies to reduce stigma and misconceptions, are essential. Continuous education and innovations, including long-acting pre-exposure prophylaxis formulations, may further enhance adoption and strengthen global HIV prevention efforts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.