Evidence map›Paper›PMID 41312379›Full record

ArticleiScience2025

Immuno-functionomics reveals geographical variation and a role for TLR8 in mRNA vaccine responses.

Wesley Huisman, Shohreh Azimi, Yen Nhi Nguyen, Alicia C de Kroon, Karin de Ruiter, Dicky L Tahapary, Mikhael D Manurung, Cilia R Pothast, Yvonne C M Kruize, Mirjam H M Heemskerk and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Wesley HuismanLeiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Shohreh AzimiLeiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Yen Nhi NguyenLeiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Alicia C de KroonLeiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Karin de RuiterLeiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Dicky L TahaparyDepartment of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Mikhael D ManurungLeiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Cilia R PothastDepartment of Hematology, Leiden University Medical Center, Leiden, the Netherlands.
Yvonne C M KruizeLeiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Mirjam H M HeemskerkDepartment of Hematology, Leiden University Medical Center, Leiden, the Netherlands.
Taniawati SupaliDepartment of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Leo G VisserLeiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Anna H E RoukensLeiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Maria YazdanbakhshLeiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
Simon P JochemsLeiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The innate immune system plays a pivotal role in pathogen defense via pattern recognition receptor sensing, initiating responses upon infection or vaccination. Understanding its functional capacity is crucial for deciphering correlates of vaccine efficacy and understanding responses to infection. Here, we developed a holistic approach to study immune function, generating >3,100 readouts across 16 cell types, 18 pattern recognition receptors, and 11 produced cytokines using spectral flow cytometry. To explore geographical variation, we compared Europeans and urban and rural Indonesians. We observed different immune responses, such as increased interleukin (IL)-1β production in rural Indonesians and impaired interferon (IFN) γ production by innate lymphocytes after Toll-like receptor (TLR) 8 stimulation. In Europeans vaccinated with mRNA-1273, baseline IFNγ production by innate lymphocytes correlated with SARS-CoV-2 spike-specific immune responses.

Indexed as

Health sciencesImmunologyMedical specialtyMedicine

Identifiers

PMID41312379
PMCPMC12651802

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.