Evidence map›Paper›PMID 41312377›Full record

ArticleiScience2025

Reading about sensations recruits the posterior insula: An intracranial EEG study.

William Dupont, Vincent Dornier, Richard Palluel-Germain, Alexis Robin, Jean-Philippe Lachaux, Philippe Kahane, Lorella Minotti, Juan R Vidal, Marcela Perrone-Bertolotti

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

William DupontUniversity Grenoble Alpes, University Savoie Mont Blanc, CNRS LPNC UMR5105, 38000 Grenoble, France.
Vincent DornierUniversity Grenoble Alpes, University Savoie Mont Blanc, CNRS LPNC UMR5105, 38000 Grenoble, France.
Richard Palluel-GermainUniversity Grenoble Alpes, University Savoie Mont Blanc, CNRS LPNC UMR5105, 38000 Grenoble, France.
Alexis RobinNeurology Department, University Hospital of Grenoble, Grenoble, France.
Jean-Philippe LachauxINSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, EDUWELL Team, 69000 Lyon, France.
Philippe KahaneNeurology Department, University Hospital of Grenoble, Grenoble, France.
Lorella MinottiNeurology Department, University Hospital of Grenoble, Grenoble, France.
Juan R VidalUniversity Grenoble Alpes, University Savoie Mont Blanc, CNRS LPNC UMR5105, 38000 Grenoble, France.
Marcela Perrone-BertolottiUniversity Grenoble Alpes, University Savoie Mont Blanc, CNRS LPNC UMR5105, 38000 Grenoble, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

How do we assess the meaning conveyed by words and sentences such as "it burns me" or "I feel cold"? As an alternative to symbolic and abstract semantic representation, embodied cognition suggests mental simulations of bodily experiences through sensorimotor activation. We recorded intracranial neural activity in human patients while they read short sentences related to abstract, action, and sensation semantic categories. Our results revealed an early functional dissociation between anterior and posterior insula: anterior insula showed a non-selective response across all semantic categories, whereas posterior insula presented an early selective response (around 170 ms) for sensation-related only. Furthermore, the intensity of this selective neural response in the posterior insula varied according to the intensity of subjective perceived pain evoked by the sentence. These results provide direct intracranial evidence for body sensation-related mechanisms in language comprehension.

Indexed as

Biological sciencesClinical neuroscienceNatural sciencesNeuroscience

Identifiers

PMID41312377
PMCPMC12648984

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.