ArticleFrontiers in neurology2025
Association between white matter microstructural and functional abnormalities and clinical characteristics in migraine without aura: a mediation analysis.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Migraine without aura (MWoA) is a neurological disorder associated with structural and functional abnormalities in white matter (WM). However, interactions between clinical characteristics and WM abnormalities of microstructure and function in MWoA have remained underexplored. In this study, we aimed to investigate these associations and broaden the understanding of the pathophysiology of MWoA. Methods: A total of 51 MWoA patients and 51 healthy controls (HCs) underwent magnetic resonance imaging (MRI). Microstructural WM abnormalities were assessed using tract-based spatial statistics (TBSS). Functional alterations were evaluated by measuring the amplitude of low-frequency fluctuation (ALFF) and degree centrality (DC). Spearman's rank correlation was used to assess the association between these abnormalities and clinical characteristics such as frequency, intensity, and disease progression of MWoA. We also conducted a region-level functional connectivity analysis, followed by mediation analysis to explore potential pathways linking WM abnormalities to clinical characteristics. Results: This study showed that, compared to HCs, MWoA patients showed decreased fractional anisotropy (FA), axial dispersion (AD), and DC and increased ALFF in the left frontopontine (FPT_L), decreased FA and AD in the forceps major (CC_ForcepsMajor), and decreased ALFF in the forceps minor (CC_ForcepsMinor). Among them, ALFF in the CC_ForcepsMinor and DC, FA, and AD in the FPT_L were inversely correlated with disease duration ( Conclusion: This study reveals concomitant alterations in the function and microstructure of WM in the CC subregions and the FPT_L among MWoA patients. These alterations are significantly correlated with clinical characteristics and suggest that these abnormalities in functional fluctuations and WM integrity may serve as mediators between reduced network integration and disease duration in MWoA. These findings support the WM abnormality hypothesis and deepen our understanding of the pathophysiological mechanisms underlying MWoA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.