ArticleBlood red cells & iron2025
Red cell physiologic stress results in lower quality transfusions: a randomized trial in adults with sickle cell disease.
Article in Blood red cells & iron, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
People with sickle cell disease (SCD) may be transfused with red cell units that are near the end of their storage life, exposing them to components of the red cell storage lesion. This study evaluated the clinical impact of storage age and red cell distress markers on chronically transfused adults with SCD. This randomized prospective clinical trial recruited 26 chronically transfused adult patients (aged >16 years) with SCD; 13 participants were randomized to each study arm, that is, targeted to receive only ≥30-day or ≤10-day stored red cell units for 3 consecutive outpatient transfusion events. The red cell units were evaluated via quantification of surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE). Differences in key clinical variables were also evaluated. We show that patients receiving units with higher surface-exposed PS and PE, regardless of storage age, had a reduced hemoglobin (Hb) increment at 2 weeks (PS-PE high, 0.59 g/dL; PS-PE low, 1.04 g/dL;
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