ArticleSkin health and disease2025
Unravelling the causal link between gut microbiota and acne risk using a genetic approach.
Article in Skin health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Acne is a common inflammatory dermatological condition that can have detrimental psychological consequences due to its visible lesions and scarring. Recent studies suggest a potential role of gut microbiota in acne development; however, the evidence remains inconclusive and might be subject to various confounders. Objectives: To investigate the causal relationship between gut microbiota and acne. Methods: This study investigated the causal relationship between gut microbiota and acne using a two-sample Mendelian randomization (MR) approach with large-scale genome-wide association study summary statistics. To ascertain the direction of causality and the independent effect of gut microbiota, reverse MR and multivariable MR accounting for dietary phenotypes were performed. Results: Higher abundances of the Conclusions: These findings provide further evidence of a causal relationship between gut microbial composition and acne, highlighting the role of gut microbiota in developing more targeted and possibly less harmful alternatives to current acne management strategies.
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