Systemic Toxicity Profile of Chemotherapeutic Agents in a Wistar Rat Model: A Preliminary Report.

Joseph Kathare, James Mbaria, Catherine Kaluwa, Issac Mapenay, Gervason Moriasi

Abstract read

In one paragraph

Article in Journal of toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joseph KathareDepartment of Public Health, Pharmacology, and Toxicology, University of Nairobi, P.O. Box 29053 00625, Nairobi, Kenya.ORCID https://orcid.org/0000-0002-1418-5857

James MbariaDepartment of Public Health, Pharmacology, and Toxicology, University of Nairobi, P.O. Box 29053 00625, Nairobi, Kenya.

Catherine KaluwaDepartment of Public Health, Pharmacology, and Toxicology, University of Nairobi, P.O. Box 29053 00625, Nairobi, Kenya.

Issac MapenayDepartment of Public Health, Pharmacology, and Toxicology, University of Nairobi, P.O. Box 29053 00625, Nairobi, Kenya.

Gervason MoriasiDepartment of Medical Biochemistry, Medical School, Mount Kenya University, P.O. Box 342-0100, Thika, Kenya.ORCID https://orcid.org/0000-0001-5604-9987

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemotherapeutic agents are pivotal in cancer management, yet their utility is constrained by pronounced systemic and organ-specific toxicity, necessitating rigorous preclinical evaluation to enhance their safe application in oncology. This study examined the hematological, biochemical, electrolyte, and histopathological effects of seven chemotherapeutic drugs-docetaxel (10 mg/kg body weight), doxorubicin (10 mg/kg), paclitaxel (4 mg/kg), oxaliplatin (4 mg/kg), cisplatin (2 mg/kg), cytarabine (50 mg/kg), and cyclophosphamide (10 mg/kg)-and a phosphate-buffered saline (PBS) control (10 mL/kg) in male Wistar rats (

Indexed as

biochemical markerschemotherapy-induced toxicityelectrolyte imbalanceshematological parametersOECD guideline 425

Identifiers

PMID41312216

DOI10.1155/jt/8811238

PMCPMC12657097

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.