Evidence map›Paper›PMID 41312200›Full record

ReviewFood chemistry: X2025

Plant protein-phenolic acids as novel food-grade synergistic modulators of neuronal function: A review.

Xiaoyu Zhang, Yutong Zheng, Xinyu Wang, Jiannan Yan, Jingsheng Liu, Hao Zhang

Abstract readReview
In one paragraph

Review in Food chemistry: X, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaoyu ZhangCollege of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China.
Yutong ZhengCollege of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China.
Xinyu WangCollege of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China.
Jiannan YanCollege of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China.
Jingsheng LiuCollege of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China.
Hao ZhangCollege of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With modernization, changing lifestyles, and the accelerating pace of global aging, addressing issues such as emotional instability, high incidence of neurodegenerative diseases, and cognitive decline has become paramount. When plant proteins and phenolic acids act independently on neurons, their promotional effects remain relatively limited. However, upon interacting through non-covalent and/or covalent bonds, the spatial structure of plant proteins undergoes alteration, providing key precursors for neurotransmitters. Encapsulated within the plant protein structure, phenolic acids exhibit significantly enhanced stability, enabling more effective neuroprotective functions. Their synergistic action promotes neurotransmitter release while simultaneously activating key signaling pathways, regulating gut microbiota, and generating neuroactive metabolites. This establishes a crucial foundation for further exploration in neuronal regulation and functional food development.

Indexed as

InteractionNeuronPhenolic acidPlant proteinSynergy

Identifiers

PMID41312200
PMCPMC12648587

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.