ArticleNature and science of sleep2025
Association of Novel Sleep EEG Biomarkers with All-Cause Mortality in a Large Community-Based Cohort.
Article in Nature and science of sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: The prognostic value of sleep depth remains poorly understood. The odds ratio product (ORP) is a novel electroencephalogram-based biomarker of sleep depth. We investigated the association between ORP-derived biomarkers and all-cause mortality in a large community-based cohort. Methods: We analyzed 5802 Sleep Heart Health Study participants. A suite of ORP biomarkers was derived from baseline polysomnography, including mean ORP values across sleep stages, change in ORP across the night (ΔORP), interhemispheric sleep depth coherence (ORP Results: During 11.0 years of follow-up, 1305 deaths occurred. After multivariable adjustment and FDR correction, higher ORP Conclusion: ORP-derived biomarkers are independently associated with all-cause mortality and complement conventional sleep metrics in refining mortality risk stratification. Identified threshold effects for several ORP parameters may provide potential cutoff points for clinical intervention.
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