Evidence map›Paper›PMID 41312184›Full record

ArticleMultiple sclerosis journal - experimental, translational and clinical

Retinal ganglion cell loss is associated with multimodal visual dysfunction following demyelinating optic neuritis.

Mustafa Subhi, Sargis Manukyan, Gabriela Zabala, Laura Locke, Brooke Guerrero, Marwa Kaisey, Afshin James Khodabakhsh, Aaron Carass, Jerry L Prince, Shiv Saidha and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mustafa SubhiVisual Outcomes Laboratory, Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID https://orcid.org/0009-0009-3448-7930
Sargis ManukyanVisual Outcomes Laboratory, Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Gabriela ZabalaVisual Outcomes Laboratory, Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Laura LockeDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Brooke GuerreroDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Marwa KaiseyDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Afshin James KhodabakhshDepartment of Ophthalmology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Aaron CarassDepartment of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, USA.
Jerry L PrinceDepartment of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD, USA.
Shiv SaidhaDivision of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.ORCID https://orcid.org/0000-0001-6387-0714
Peter A CalabresiDivision of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Nancy L SicotteDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Pascal SatiDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-6763-0125
Omar Al-LouziVisual Outcomes Laboratory, Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0003-2260-5660

Funding

OCT and OCTA image processing for retinal assessment of people with MSR01EY032284 · NEI · JOHNS HOPKINS UNIVERSITY · PI PRINCE, JERRY L · 2021 to 2024
$1.8M
NEI NIH HHS R01 EY032284
6 · The paper itself

Abstract

Background: Optic neuritis (ON) is a common manifestation of multiple sclerosis and related disorders (MSRD) characterized by retinal neurodegeneration, including thinning of ganglion cell-inner plexiform layer (GCIPL). Compared to absolute values, inter-eye differences (IED) account for variation in baseline structure and function before ON. Objectives: To determine retinal layer IED thresholds associated with multimodal visual dysfunction after unilateral demyelinating ON. Methods: In this cross-sectional study, MSRD participants with and without a history of unilateral ON, and healthy controls underwent optical coherence tomography, best-corrected visual acuity, 2.5% and 1.25% low-contrast letter acuity (LCLA), standard automated perimetry, and color vision testing. Results: Sixty-six participants with MSRD (33 with unilateral ON history, 33 without ON history) and 15 healthy controls were included. For the ON cohort, a GCIPL IED threshold of 6.5% was associated with dyschromatopsia (AUC = 0.76, Conclusions: GCIPL IED thresholds more accurately reflect multimodal visual dysfunction after ON compared to other retinal layer IED.

Indexed as

color visionganglion-inner plexiform cell layerMultiple sclerosisoptical coherence tomographyoptic neuritisvisual acuityvisual field

Identifiers

PMID41312184
PMCPMC12647537

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.