SynthesisInternational journal of public health2025
Inflammatory and Carcinogenic Biomarker Signatures in E-Cigarette Users: A Comprehensive Meta-Analysis of ∼24,000 Adults.
Synthesis in International journal of public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Differential Enhancement of Cigar Tobacco Leaf Aroma by Single-Strain Inoculation withJournal of microbiology and biotechnology · 2026Article
- Toxicity and Appeal of Flavoured E-Cigarettes and Flavour Ban Outcomes: A Narrative Review.International journal of environmental research and public health · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: This meta-analysis examined the association between electronic cigarette (e-cig) use and biomarkers related to lung inflammation and carcinogenesis. Methods: A systematic review of PubMed, Scopus, Web of Science, EMBASE, and Cochrane Library (2014-April 2024) identified 16 studies including 24,079 adults. Biomarkers from urine, saliva, and plasma-cotinine, NNAL, NAT, and interleukins-were analyzed using one-way ANOVA and Tukey's post-hoc tests. The GRADE framework assessed evidence certainty and risk of bias. Results: Among participants, 27.2% were smokers, 2.7% e-cig users, 66.0% non-smokers, and 4.1% dual users. E-cig users showed higher salivary cotinine than non-smokers (p = 0.033) but not smokers (p = 0.99). NNAL was significantly elevated in smokers (p = 0.035). E-cig users had increased inflammatory markers (IL-6, TNF-α) compared with non-smokers but lower than smokers. Carcinogenic biomarkers were present in e-cig users at reduced concentrations versus smokers. GRADE indicated low to high certainty with no or moderate bias. Conclusion: E-cigarette use is associated with biomarker alterations indicating inflammation and potential carcinogenesis, paralleling some effects of traditional smoking. Standardized longitudinal studies are needed to establish causality and long-term risks.
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Registered trials
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